The somatosensory evoked potential as a noninvasive method to determine flow rates for hyperosmotic disruption of the blood-brain barrier

Neurosurgery
P C WarnkeD R Groothuis

Abstract

We have developed a noninvasive method to determine the flow rates necessary to produce hyperosmotic blood-brain barrier disruption in individual animals. The method uses the intracarotid infusion of 0.9% NaCl at increasing flow rates, while concurrently measuring the amplitude of the somatosensory evoked potential (SSEP). For these studies, dogs were prepared with craniotomies to visualize the duration of cortical blanching. Saline (0.9% NaCl) was infused into the internal carotid artery at flow rates of 0.9 to 2.1 ml/s for periods from 2 to 40 seconds while the SSEP was concurrently measured in six 30-second epochs before, during, and after the infusion. There was a linear relationship between the duration of cortical blanching (from 2 to 30 seconds) and amplitude suppression of the major negative deflection of the SSEP. This relationship allowed us to predict the intracarotid infusion rate necessary to achieve cortical blanching for periods of 20 seconds or more. Subsequent infusion of 1.4 or 1.6 osmolar mannitol at the predicted flow rate resulted in more pronounced suppression of the SSEP than did 0.9% NaCl and produced disruption of the blood-brain barrier as documented by computed tomographic scans with contrast enhancem...Continue Reading

Citations

Jul 1, 1993·Addiction·F Holdener

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