The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion.

Radiation Research
Qiang FuMartin Hauer-Jensen

Abstract

Somatostatin analogs ameliorate intestinal injury after localized irradiation. This study investigated whether SOM230, a novel, metabolically stable analog with broad receptor affinity, reduces intestinal injury and lethality in mice exposed to total-body irradiation (TBI). Male CD2F1 mice were exposed to 7-15 Gy TBI. Twice-daily administration of SOM230 (1, 4 or 10 mg/kg per day) or vehicle was started either 2 days before or 4 h after TBI and continued for either 14 or 21 days. Parameters of intestinal and hematopoietic radiation injury, bacterial translocation, and circulating cytokine levels were assessed. Animal survival was monitored for up to 30 days. SOM230 increased survival (P < 0.001) and prolonged survival time (P < 0.001) whether administration was initiated before or after TBI. There was no benefit from administration for 21 compared to 14 days. The survival benefit of SOM230 was completely reversed by co-administration of pancreatic enzymes (P = 0.009). Consistent with the presumed non-cytoprotective mechanism of action, SOM230 did not influence hematopoietic injury or intestinal crypt lethality. However, SOM230 preserved mucosal surface area (P < 0.001) and reduced bacterial translocation in a dose-dependent man...Continue Reading

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Citations

Jan 15, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jessica L PalmerElizabeth J Kovacs
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Nov 30, 2018·International Journal of Colorectal Disease·Gabriel J SeifertClaudia Laessle
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro

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Methods Mentioned

BETA
Assay
PCR
enzyme-linked immunosorbent assay
antisense oligonucleotides

Software Mentioned

NCSS
SOM230

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