The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion.

Radiation Research
Qiang FuMartin Hauer-Jensen


Somatostatin analogs ameliorate intestinal injury after localized irradiation. This study investigated whether SOM230, a novel, metabolically stable analog with broad receptor affinity, reduces intestinal injury and lethality in mice exposed to total-body irradiation (TBI). Male CD2F1 mice were exposed to 7-15 Gy TBI. Twice-daily administration of SOM230 (1, 4 or 10 mg/kg per day) or vehicle was started either 2 days before or 4 h after TBI and continued for either 14 or 21 days. Parameters of intestinal and hematopoietic radiation injury, bacterial translocation, and circulating cytokine levels were assessed. Animal survival was monitored for up to 30 days. SOM230 increased survival (P < 0.001) and prolonged survival time (P < 0.001) whether administration was initiated before or after TBI. There was no benefit from administration for 21 compared to 14 days. The survival benefit of SOM230 was completely reversed by co-administration of pancreatic enzymes (P = 0.009). Consistent with the presumed non-cytoprotective mechanism of action, SOM230 did not influence hematopoietic injury or intestinal crypt lethality. However, SOM230 preserved mucosal surface area (P < 0.001) and reduced bacterial translocation in a dose-dependent man...Continue Reading


Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·N H Terry, E L Travis
Nov 1, 1985·Acta Radiologica. Oncology·M Hauer JensenK Nygaard
Jun 1, 1986·Journal of Microscopy·A J BaddeleyL M Cruz-Orive
Jan 1, 1970·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H R Withers, M M Elkind
Nov 1, 1970·Archives of Surgery·L MorgensternN Hiatt
Oct 1, 1984·Infection and Immunity·I BrookR I Walker
Apr 1, 1997·The American Journal of Physiology·A TodiscoT Yamada
Jul 11, 1998·Acta Oncologica·I A Gómez-de-SeguraE De Miguel
Dec 9, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T AlexandridesF Kalfarentzos
Dec 29, 1999·International Journal of Radiation Oncology, Biology, Physics·J WangM Hauer-Jensen
Mar 15, 2000·Molecular and Cellular Endocrinology·P G MylonasT K Alexandrides
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Heather R WilkinsP Kay Lund
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Melek N YavuzHalil Kavgaci
Dec 7, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C A RagusoC Pichard
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Ludy C H W LutgensPhilippe Lambin
Nov 25, 2003·Hematology·Nicholas DainiakAnn M Farese
May 19, 2004·Journal of Neurochemistry·Gisela OliasWolfgang Meyerhof
Jun 3, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Iván Pérez-NeriCamilo Ríos
Jun 5, 2004·Regulatory Peptides·Vassilis ValatasElias A Kouroumalis
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Geert W Schmid-Schönbein, Tony E Hugli
Dec 27, 2005·Regulatory Peptides·John Y KaoJuanita L Merchant
Dec 27, 2005·Peptides·Semra Doğru AbbasoğluGülçin Toker
Jan 18, 2006·Digestive Diseases and Sciences·Vakur OlgaçGülçin Toker
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bradley W SchullerJeffrey A Coderre
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Junru WangMartin Hauer-Jensen
Jun 2, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfDennis Confer
Feb 17, 2007·Shock·Alexander H PennGeert W Schmid-Schönbein
Jun 26, 2007·World Journal of Gastroenterology : WJG·Ludy Lutgens, Philippe Lambin
Aug 22, 2007·The British Journal of Radiology·J Wang, M Hauer-Jensen
Oct 3, 2007·Cancer Research·Marjan BoermaMartin Hauer-Jensen
Jan 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Jimmy A RotoloZvi Fuks
Jan 29, 2008·Recent Patents on Anti-cancer Drug Discovery·Gabriela Melen-MuchaHenryk Stepien
Apr 29, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pascal CrennLuc Cynober
May 15, 2008·The Journal of Clinical Endocrinology and Metabolism·Robert D Murray, Shlomo Melmed
May 13, 2009·Biometrics·Ralph L KodellMartin Hauer-Jensen

❮ Previous
Next ❯


Jan 15, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jessica L PalmerElizabeth J Kovacs
Jan 10, 2012·Current Opinion in Supportive and Palliative Care·Maaike Berbée, Martin Hauer-Jensen
Apr 2, 2014·Nature Reviews. Gastroenterology & Hepatology·Martin Hauer-JensenH Jervoise N Andreyev
May 23, 2014·The New England Journal of Medicine·Peter J AllenWilliam R Jarnagin
Feb 14, 2013·Molecular BioSystems·Sanchita P GhoshAmrita K Cheema
Mar 23, 2011·International Journal of Radiation Biology·Jacqueline P Williams, William H McBride
Dec 22, 2009·Expert Opinion on Therapeutic Patents·Francis DumontPierre Bischoff
Oct 16, 2014·Expert Opinion on Therapeutic Patents·Vijay K SinghThomas M Seed
Mar 10, 2012·Radiation Research·Reid D LandesMartin Hauer-Jensen
Oct 28, 2019·British Journal of Pharmacology·Huihong ZengLijian Shao
Nov 30, 2018·International Journal of Colorectal Disease·Gabriel J SeifertClaudia Laessle
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro

❮ Previous
Next ❯

Methods Mentioned

enzyme-linked immunosorbent assay
antisense oligonucleotides

Software Mentioned


Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis