The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertension in rats

Journal of Cellular and Molecular Medicine
Marc MejiasMercedes Fernandez

Abstract

Angiogenesis is an important determinant of the pathophysiology of portal hypertension contributing to the formation of portosystemic collateral vessels and the hyperdynamic splanchnic circulation associated to this syndrome. Somatostatin and its analogues, like octreotide, have been shown to be powerful inhibitors of experimental angiogenesis. To determine whether octreotide has angioinhibitory effects in portal hypertensive rats. Partial portal vein-ligated (PPVL) rats were treated with octreotide or vehicle during 4 or 7 days. Splanchnic neovascularization and VEGF expression were determined by histological analysis and western blotting. Expression of the somatostatin receptor subtype 2 (SSTR2), which mediates the anti-angiogenic effects of octreotide, was also analyzed. Formation of portosystemic collaterals (radioactive microspheres) and hemodynamic parameters were also measured. Octreotide treatment during 4 days markedly and significantly decreased splanchnic neovascularization, VEGF expression by 63% and portal pressure by 15%, whereas portosystemic collateralization and splanchnic blood flow were not modified. After 1 week of octreotide injection, portal pressure was reduced by 20%, but inhibition of angiogenesis escap...Continue Reading

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Citations

May 15, 2010·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Darko MirkovićMilan Jovanović
Jan 26, 2016·Current Medical Research and Opinion·Dmitry Victorovich Garbuzenko
Jul 16, 2010·Gastroentérologie Clinique Et Biologique·O Rosmorduc
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc MejiasMercedes Fernandez
May 6, 2016·Expert Opinion on Emerging Drugs·Harikumar NairJaime Bosch
Jan 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui MaXiujun Cai
Dec 21, 2018·Expert Opinion on Therapeutic Targets·Isabelle Castan-LaurellPhilippe Valet
Sep 11, 2018·World Journal of Gastroenterology : WJG·Dmitry Victorovich GarbuzenkoEvgeniy Leonidovich Kazachkov
Jun 3, 2015·World Journal of Gastroenterology : WJG·Dmitry Victorovich Garbuzenko

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