The somatotopy of tic inhibition: Where and how much?

Movement Disorders : Official Journal of the Movement Disorder Society
Christos GanosAlexander Münchau

Abstract

Tics are the hallmark feature of Tourette syndrome. The basic phenomenological and neurophysiological characteristics of tics have been widely investigated. Interestingly, the spatial distribution of tics across different body parts has received little attention. No previous study has investigated whether the capacity for voluntary tic inhibition also varies across body parts. We analyzed video sequences of 26 adolescents with Tourette syndrome in a "tic freely" condition, and in a "voluntary tic inhibition" condition, to obtain absolute tic counts for different body parts. Two measures of the spatial distribution of tics were then analyzed. Linear regression analyses were employed to investigate the relation between the contribution of each body part to overall tic behavior and the ability to inhibit tics in that body part, averaged over our patient group. Tic distribution across patients showed a characteristic somatotopic pattern, with the face most strongly represented. A significant negative relation was found between the ability to inhibit tics and pooled tic frequency across body parts. The body parts that exhibited the fewest tics were the ones for which tic inhibition was most effective. Our data are consistent with th...Continue Reading

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Citations

Feb 29, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Valerie C BrandtAlexander Münchau
Sep 18, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Yulia WorbeAndreas Hartmann
Mar 31, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Christos Ganos, John Rothwell
Jul 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Dorin YaelIzhar Bar-Gad
Dec 22, 2017·Annals of Neurology·Sinem Tunc, Alexander Münchau
Mar 7, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Christos GanosPatrick Haggard
Nov 1, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Christos GanosJohn Rothwell
May 7, 2020·Cognitive Neuropsychiatry·Andrea E CavannaStefano Seri
May 29, 2020·Brain : a Journal of Neurology·Maximilian KleimakerChristian Beste
Jun 17, 2016·Current Opinion in Neurology·Christos Ganos
Jul 10, 2018·Movement Disorders Clinical Practice·Bettina BalintKailash P Bhatia
Oct 15, 2019·Journal of Child Neurology·Chandler E Gill, Katie Kompoliti
May 7, 2020·European Child & Adolescent Psychiatry·Tamara PringsheimDavide Martino
Jun 8, 2018·Frontiers in Psychiatry·Christine A ConeleaMatthew Capriotti
Mar 21, 2019·Frontiers in Psychiatry·Charlotte L RaeAnil K Seth
Mar 20, 2021·NeuroImage. Clinical·Emily MielkeAlexander Münchau
May 14, 2021·IScience·Esther Vinner HardufIzhar Bar-Gad
May 16, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Simon Morand-BeaulieuDenis G Sukhodolsky
Jul 3, 2021·Journal of Clinical Medicine·Keisuke Ueda, Kevin J Black
Jun 29, 2021·Current Developmental Disorders Reports·Keisuke UedaKevin J Black
Jul 23, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tamara Pringsheim, Davide Martino
Aug 14, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Tamara PringsheimDavide Martino

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