The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Manuela Torres Andion VidalJean Nunes Dos Santos

Abstract

The pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) are common tumors arising from salivary glands whose histopathology is heterogeneous. The sonic hedgehog signaling pathway (Hh) and signal transducer and activator of transcription 3 (STAT3) play important roles in cell proliferation, favoring tumor growth. The aim of this investigation was to study components of the Hh pathway, as well as STAT3 in salivary gland neoplasms in an attempt to add information about the biological characteristics of these neoplasms. We used 9 cases of PA, 17 cases of ACC, and 20 cases of MEC. Using immunohistochemistry, SHH, GLI1, SUFU, HHIP, and STAT3 were investigated. For comparative purposes, MCM3 (cellular proliferation marker) was also included. In PA, there was high expression of cytoplasmic SHH and SUFU and low expression of STAT3 and MCM3. In the ACC, there was high expression of GLI1, HHIP, and STAT3 and low expression of SHH, SUFU, and MCM3. In the MEC, we observed high expression of SHH, GLI1, SUFU, and HHIP and low expression of STAT3 and MCM3. There was a statistically significant difference between SHH (p = 0.0064), STAT3 (p = 0.0003), and MCM3 (p = 0.0257) when all tumors were compared an...Continue Reading

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Citations

Mar 23, 2019·Expert Opinion on Investigational Drugs·Stefano CavalieriSalvatore Alfieri
Aug 14, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Vinicius Rio Verde Melo MunizJean Nunes Dos Santos
Aug 10, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rebeca C M DantasClarissa A G Rocha

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