The Sooner the Better? How Symptom Interval Correlates With Outcome in Children and Adolescents With Solid Tumors: Regression Tree Analysis of the Findings of a Prospective Study

Pediatric Blood & Cancer
Andrea FerrariLuigi Mariani

Abstract

The potential impact of diagnostic delays on patients' outcomes is a debated issue in pediatric oncology and discordant results have been published so far. We attempted to tackle this issue by analyzing a prospective series of 351 consecutive children and adolescents with solid malignancies using innovative statistical tools. To address the nonlinear complexity of the association between symptom interval and overall survival (OS), a regression tree algorithm was constructed with sequential binary splitting rules and used to identify homogeneous patient groups vis-à-vis functional relationship between diagnostic delay and OS. Three different groups were identified: group A, with localized disease and good prognosis (5-year OS 85.4%); group B, with locally or regionally advanced, or metastatic disease and intermediate prognosis (5-year OS 72.9%), including neuroblastoma, Wilms tumor, nonrhabdomyosarcoma soft tissue sarcoma, and germ cell tumor; and group C, with locally or regionally advanced, or metastatic disease and poor prognosis (5-year OS 45%), including brain tumors, rhabdomyosarcoma, and bone sarcoma. The functional relationship between symptom interval and mortality risk differed between the three subgroups, there being ...Continue Reading

References

Nov 1, 1991·The Journal of Pediatrics·B H PollockT J Vietti
Jul 1, 1986·American Journal of Diseases of Children·L E FloresA H Ragab
Jun 1, 1993·Archives of Disease in Childhood·V SahaG MacKinlay
Dec 24, 1997·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·W A BleyerR S Ungerleider
Jan 6, 2001·Acta Oncologica·H ThulesiusA Håkansson
Mar 22, 2002·The Lancet Oncology·R Hollis, S Morgan
Jul 13, 2002·Medical and Pediatric Oncology·Arturo Fajardo-GutiérrezMaría del Carmen Martínez-García
Feb 25, 2003·Cancer·Lihua LiuUNKNOWN Surveillance, Epidemiology and End Results Childhood Cancer Linkage Group
Dec 9, 2003·Pediatric Hematology and Oncology·M HaimiM Weyl Ben Arush
Sep 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GoyalT O B Eden
Jan 26, 2007·Cancer Treatment Reviews·Andrea Ferrari, Archie Bleyer
Dec 28, 2007·Journal of Child Neurology·Bettina C ReuleckeGerhard Kurlemann
May 6, 2008·Pediatric Blood & Cancer·Tam Dang-TanEduardo L Franco
Jun 10, 2008·European Journal of Pediatrics·Karel KukalMichael A Grotzer
Jan 13, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrea FerrariGuido Pastore
Feb 24, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gemma GattaUNKNOWN EUROCARE Working Group
Sep 8, 2009·Journal of Pediatric Hematology/oncology·Amos Hong Pheng LohChan Hon Chui
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Tam Dang-TanEduardo L Franco
Aug 6, 2010·Cancer Epidemiology·Motti HaimiMyriam Weyl Ben Arush
Mar 9, 2011·Pediatric Blood & Cancer·Emre CecenNur Olgun
Aug 27, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Vered ShayShlomi Constantini
Mar 12, 2013·Archives of Disease in Childhood·Christopher David LethabyRichard G Feltbower
Nov 23, 2013·Archives of Disease in Childhood·Elise LaunayMartin Chalumeau
Jan 7, 2014·Journal of Pediatric Hematology/oncology·Ronald D Barr
May 21, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-François BrasmeNathalie Gaspar
Dec 3, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea FerrariMaura Massimino

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Citations

Nov 8, 2016·Bulletin du cancer·Emmanuel DesandesUNKNOWN le Réseau français des registres de cancers
Jul 24, 2018·Journal of Adolescent and Young Adult Oncology·Lesley SmithDan Stark
Mar 27, 2019·Journal of Adolescent and Young Adult Oncology·Tristan PettitRuth Spearing
Apr 23, 2020·Journal of Adolescent and Young Adult Oncology·Elena Pagani BagliaccaAndrea Ferrari
May 8, 2020·Journal of Adolescent and Young Adult Oncology·Eugenie YoungerWinette T A van der Graaf
May 9, 2019·Pediatric Blood & Cancer·Sara StonehamLindsay Frazier
Aug 8, 2020·Pediatric Blood & Cancer·Stefano ChiaravalliMaura Massimino
Oct 7, 2017·Indian Pediatrics·Deepak BansalKatragadda Lakshmi Narasimha Rao
Apr 4, 2017·Pediatric Blood & Cancer·Andrea Ferrari, Ronald D Barr
Jul 15, 2020·Pathology Oncology Research : POR·Eduardo Javier Barragán-PérezChiharu Murata
Oct 23, 2020·Pediatric Blood & Cancer·Clarissa MattosinhoKarina Ribeiro
Apr 14, 2021·Journal of Adolescent and Young Adult Oncology·Ivana Bozovic-SpasojevicDaniel Stark
Dec 17, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C CollignonD Orbach

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