The sorting behaviour of olfactory and vomeronasal axons during regeneration

Journal of Molecular Histology
Fatemeh ChehrehasaBrian Key

Abstract

In order to begin to understand how primary olfactory and vomeronasal organ (VNO) axons target specific regions of the olfactory bulb, we examined the sorting behaviour of these axons following neonatal unilateral olfactory bulbectomy. Bulbectomy induced widespread ipsilateral death of the primary olfactory and VNO neurons. After 4 weeks, many new sensory axons had re-grown into the cranial cavity and established a prominent plexus with evidence of dense tufts that were similar in gross appearance to glomeruli. Axons expressing the cell adhesion molecule OCAM, which normally innervate the ventrolateral and rostral halves of the main and accessory olfactory bulbs, respectively, sorted out and segregated from those axons not expressing this molecule within the plexus. In addition, VNO axons formed large discrete bundles that segregated from main olfactory axons within the plexus. Thus, VNO and primary olfactory axons as well as discrete subpopulations of both are able to sort out and remain segregated in the absence of the olfactory bulb. Sorting and convergence of axons therefore occur independently of the olfactory bulb and are probably attributable either to inherent properties of the axons themselves or to interactions betwee...Continue Reading

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Citations

Jul 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mark A JohnsonGilad Barnea
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Peter Mombaerts
Aug 24, 2018·Neural Regeneration Research·Kate BeecherFatemeh Chehrehasa
Mar 28, 2008·Neurochemical Research·Nikolaj Kulahin, Peter S Walmod
Sep 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Debasish ChaudhuriMartin Zapotocky
Oct 15, 2019·Frontiers in Molecular Neuroscience·Marziah HakimFatemeh Chehrehasa

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