The source of pretreatment serum prostate-specific antigen in clinically localized prostate cancer--T, N, or M?

International Journal of Radiation Oncology, Biology, Physics
G K ZagarsM E Sands

Abstract

Prostate-specific antigen (PSA) is an important marker for prostate cancer and has been shown to be secreted from the primary tumor and from metastases. However, the relative contribution of the primary and micrometastatic disease to the serum level of PSA in patients with clinically localized disease has not been delineated. This study addresses the source of pretreatment serum PSA in patients with clinically localized disease. The fall in serum PSA level following radical prostatectomy (280 patients; 105 T1, 165 T2, 10 T3) or definitive radiotherapy (427 patients; 122 T1, 147 T2, 158 T3/T4) was analyzed with the assumption that any fall in PSA following local treatment reflects the fraction of PSA produced in the prostate and its primary tumor. Serum PSA level became undetectable in 277 of the 280 (99%) patients within 6 months of radical prostatectomy. The three patients who did not achieve undetectable levels had postsurgical values < or = 0.9 ng/ml. Following definitive radiotherapy, nadir serum PSA values were between < or = 0.3 and 20.3 ng/ml, with mean and median values of 1.9 and 1.2 ng/ml, respectively. Nadir PSA was undetectable in 52 patients (12%). Four patients' PSA did not fall, but rose from the start, and each ...Continue Reading

References

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Citations

May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A PollackI I Rosen
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA G Ayala
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A PollackM E Sands
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G K Zagars, A Pollack
Mar 15, 1997·International Journal of Radiation Oncology, Biology, Physics·M S AnscherM W Dewhirst
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·A Pollack, G K Zagars
Sep 24, 2011·Advances in Urology·Andreas SommerhuberWolfgang Loidl
Mar 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Chien Peter ChenI-Chow Hsu
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Fernando J BiancoJames A Eastham
Jun 17, 1998·The Journal of Urology·G F GreeneA C Von Eschenbach
Sep 5, 1998·Cancer Treatment Reviews·M Reni, A Bolognesi

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