The South West Area Mesothelioma and Pemetrexed trial: a multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication

British Journal of Cancer
C E HooperNick Maskell

Abstract

Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Consecutive patients with MPM who were considered fit for first-line chemotherapy were prospectively recruited. Patients of similar performance status opting for best supportive care were included as a comparator group. Baseline and interval CT, PET-CT and serum markers (mesothelin, fibulin-3 and neutrophil-lymphocyte ratio (NLR)) were obtained, and patients followed up for a minimum 12 months. Seventy-three patients were recruited (58 chemotherapy/15 comparator arm). Baseline TGV (total glycolytic volume on PET-CT) was an independent predictor of worse overall survival (OS) (P=0.001). Change in interval TGV(baseline/after two cycles of chemotherapy) did not predict OS or chemotherapy response on CT. Baseline NLR<4 was an independent predictor of better OS (median survival 453 (IQR 272-576) days vs NLR⩾4, 257 (IQR 147-490), P=0.002). Although baseline serum mesothelin did not predict OS, a falling level at 8 weeks significantly predicted longer time to progression (TTP) (P<0.001). Neutrophil-lymphocyte ratio and baseline TGV predict prognosis in malignant pleural mesothelioma (MPM), but P...Continue Reading

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Citations

Aug 12, 2015·British Journal of Cancer·Michaela B KirschnerGlen Reid
Oct 24, 2017·Annals of Clinical Biochemistry·David T Arnold, Nick A Maskell
Oct 28, 2017·The International Journal of Biological Markers·Jing JinWeimin Li
Sep 20, 2016·British Journal of Hospital Medicine·Duneesha de Fonseka, Nick Maskell
Jul 29, 2018·The European Respiratory Journal·Anna C BibbyNick A Maskell
Feb 9, 2017·British Journal of Cancer·David T ArnoldNick A Maskell
Jul 31, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Anna C BibbyGiuseppe Cardillo
Apr 25, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Oke GerkeWerner Vach
Apr 1, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Swati KhannaRaffit Hassan
Feb 8, 2018·Respiratory Medicine·Kevin G Blyth, Daniel J Murphy

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Methods Mentioned

BETA
imaging techniques
ELISA

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