The soybean concentrated extract proliferates the vagina of adult rats

Menopause : the Journal of the North American Menopause Society
Adriana Aparecida Ferraz CarbonelJ M Soares

Abstract

The aim of this study was to evaluate changes induced on the vagina of ovariectomized rats after treatment with soybean concentrated extract or conjugated equine estrogens and the association of both drugs. We conducted an experimental study with 50 ovariectomized rats that were randomly divided into five equal groups of 10 animals: GI received vehicle, GII received soybean concentrated extract 46 mg/kg per day, GIII received soybean concentrated extract 120 mg/kg per day, GIV received conjugated equine estrogens 50 μg/kg per day, and GV received conjugated equine estrogens 50 μg/kg and soybean concentrated extract 46 mg/kg per day. The substances were administered by gavage during 21 consecutive days. After that, the animals were killed under anesthesia and the vagina was removed for histological and immunohistochemical analysis. Data were initially submitted to analysis of variance. Whenever a significant difference was detected, the study was complemented with the Tukey-Kramer test for multiple comparisons. GII did not show any differences on the vaginal epithelium or collagen compared with GI. GIII presented an increase in vaginal epithelium and collagen amount. GIV had the highest amount of collagen and the signals of vagi...Continue Reading

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Citations

Oct 26, 2013·Climacteric : the Journal of the International Menopause Society·C P TeixeiraA F Carbonel
Jul 6, 2012·Climacteric : the Journal of the International Menopause Society·A M C FranciscoM A Haidar
Sep 23, 2014·Climacteric : the Journal of the International Menopause Society·A A Ferraz CarbonelJ M Soares
Sep 20, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ricardo Santos SimõesEdmund Chada Baracat
Nov 26, 2014·Menopause : the Journal of the North American Menopause Society·Lucio O CarmignaniAarão M Pinto-Neto
Sep 12, 2014·Revista da Associação Médica Brasileira·Leonardo Augusto LombardiEdmund Chada Baracat
Nov 3, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Adriana Aparecida Ferraz CarbonelManuel de Jesus Simões
Sep 5, 2017·Climacteric : the Journal of the International Menopause Society·A A F CarbonelM J Simões
Jul 2, 2019·Climacteric : the Journal of the International Menopause Society·A A F CarbonelM J B C Girão
May 20, 2020·Revista da Associação Médica Brasileira·Paulo Celso FrancoManuel de Jesus Simões
Jul 17, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan ZhangXiao-Hong Chen
Jan 24, 2019·Revista da Associação Médica Brasileira·Ceci Mendes Carvalho LopesEdmund C Baracat

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