PMID: 9176650May 1, 1997Paper

The Spacehaler for delivery of salbutamol: a comparison with the standard metered-dose inhaler plus Volumatic spacer device

Respiratory Medicine
K A GunawardenaG K Crompton

Abstract

The Spacehaler is a new, compact, pressurized aerosol device that uses the same canister as a conventional metered-dose inhaler (MDI). Its design, however, reduces the velocity of the aerosol cloud that emerges from the inhaler, thereby reducing the amount of the non-respirable fraction of the drug delivered to the patient. Large volume spacers achieve a similar effect, but they are bulky and therefore inconvenient to use and carry around. This study compared the bronchodilator effect of 200 micrograms salbutamol delivered by the Spacehaler to that of an MDI used with a Volumatic spacer (MDI plus spacer) in patients with reversible obstructive airways disease. Twenty-five patients with asthma, having a forced expiratory volume in 1 s (FEV1) between 50 and 90% predicted and a reversibility of > or = 15% to 200 micrograms salbutamol given by the conventional (standard) MDI entered the study. On two separate study days, they inhaled 200 micrograms salbutamol either via the Spacehaler or the MDI plus spacer. To maintain blinding, they received placebo on both study days via the alternate device. Their FEV1, forced vital capacity (FVC) and peak expiratory flow (PEF) were measured before and at regular intervals for 6 h after inhalat...Continue Reading

References

Apr 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·K F Phillips
Oct 2, 1986·The New England Journal of Medicine·M T Newhouse, M B Dolovich

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Citations

Jul 5, 2003·Advanced Drug Delivery Reviews·P W Barry, C O'Callaghan
Mar 1, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael J AsmusGuenther Hochhaus
Feb 13, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Mark W NagelJolyon P Mitchell
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·N Roche, G J Huchon
May 11, 2007·Expert Opinion on Drug Delivery·David Lewis
Aug 2, 2016·Advanced Pharmaceutical Bulletin·Sepideh MomeniHamed Hamishehkar
Nov 15, 2005·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·H S Cho, N Y Park
Jan 14, 2012·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Flávia de Barros AraújoNilton Alves de Rezende
Oct 9, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Juliana Teixeira GomesMarcelo Gervilla Gregório

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