The spatial and temporal dynamics of rabies in China.

PLoS Neglected Tropical Diseases
Jinning YuGuodong Liang

Abstract

Recent years have seen a rapid increase in the number of rabies cases in China and an expansion in the geographic distribution of the virus. In spite of the seriousness of the outbreak and increasing number of fatalities, little is known about the phylogeography of the disease in China. In this study, we report an analysis of a set of Nucleocapsid sequences consisting of samples collected through the trial Chinese National Surveillance System as well as publicly available sequences. This sequence set represents the most comprehensive dataset from China to date, comprising 210 sequences (including 57 new samples) from 15 provinces and covering all epidemic regions. Using this dataset we investigated genetic diversity, patterns of distribution, and evolutionary history. Our analysis indicates that the rabies virus in China is primarily defined by two clades that exhibit distinct population subdivision and translocation patterns and that contributed to the epidemic in different ways. The younger clade originated around 1992 and has properties that closely match the observed spread of the recent epidemic. The older clade originated around 1960 and has a dispersion pattern that suggests it represents a strain associated with a previ...Continue Reading

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Citations

Apr 20, 2014·BMC Infectious Diseases·Miao SongGuo-Dong Liang
Oct 4, 2013·Infectious Diseases of Poverty·Wenwu YinUNKNOWN Rabies Technical and Advisory Board
Oct 16, 2014·Journal of Travel Medicine·Marc T M ShawCiaran Edwards
Sep 4, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Guo Wei LiJia Hai Lu
May 29, 2015·PLoS Neglected Tropical Diseases·Jing ChenShigui Ruan
Oct 21, 2015·PLoS Neglected Tropical Diseases·Xiao-Yan TaoQing Tang
Feb 12, 2017·Mathematical Biosciences·Shigui Ruan
Jul 19, 2018·Vector Borne and Zoonotic Diseases·Xiao-Yan TaoWu-Yang Zhu
Dec 7, 2018·PLoS Pathogens·Huaiyu TianSimon Dellicour
Aug 22, 2014·Emerging Infectious Diseases·Hai-Lin ZhangQing Tang
Feb 19, 2015·PLoS Neglected Tropical Diseases·Hong-Wu YaoWu-Chun Cao
Jan 15, 2019·PLoS Neglected Tropical Diseases·Xiao-Yan TaoWu-Yang Zhu
Jul 6, 2017·Infectious Diseases of Poverty·Xue-Yong HuangBian-Li Xu
Jun 14, 2013·Virologica Sinica·Xiaoyan TaoGuodong Liang
Feb 6, 2021·The Journal of General Virology·Rajesh Raghunanth PharandeSandeepan Mukherjee

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Software Mentioned

PHYLIP
R
Java
BEAST
MigraPhyla
UniFrac
PAUP
COFFEE
TMRCA
MODELTEST

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