The spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development

The European Journal of Neuroscience
Yury M MorozovT F Freund

Abstract

GABAergic synaptic transmission is efficiently controlled by endogenous cannabinoids in cortical structures. Fatty acid amide hydrolase (FAAH) is one of the metabolizing enzymes of endocannabinoids in the brain. In this study we investigated the cellular and subcellular distribution of FAAH at various timepoints during the first postnatal weeks, when GABA is still depolarizing, and plays a crucial role in network events. FAAH immunoreactivity is strong in the CA3 region already at postnatal day 0 (P0), but in CA1 only after P8. During this period, FAAH levels in hilar mossy cells decrease and in granule cells slowly increase. Pyramidal cells express FAAH first in the soma and proximal dendrites, and gradually in more distal segments, reaching adult levels in the most distal dendrites only at P22. Transient expression of FAAH was found in a small number of stratum radiatum cells that may be interneurons and in ependymal cells at the border of the alveus and corpus callosum between P2 and P8. At the ultrastructural level, FAAH distribution at all ages was very similar to the adult pattern, i.e. it was largely associated with the membrane of cytoplasmic vesicles, mitochondria and endoplasmic reticulum. During postnatal development...Continue Reading

References

Dec 1, 1991·Trends in Neurosciences·E CherubiniY Ben-Ari
Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Nov 29, 1986·Brain Research·G Buzsáki
Nov 8, 1985·The Journal of Comparative Neurology·F B Gaarskjaer
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Jun 1, 1984·Journal of Neurochemistry·V NatarajanH H Schmid
Sep 1, 1993·Biochemical Pharmacology·D G Deutsch, S A Chin
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Nov 19, 1997·Trends in Neurosciences·Y Ben-AriJ L Gaiarsa
Sep 21, 2000·The European Journal of Neuroscience·N HájosT F Freund
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B F CravattA H Lichtman
Apr 27, 2002·Science·Rachel I Wilson, Roger A Nicoll
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·T P DinhD Piomelli
Sep 5, 2002·Nature Reviews. Neuroscience·Yehezkel Ben-Ari
Jul 5, 2003·Physiological Reviews·Tamas F FreundDaniele Piomelli
Sep 6, 2003·The European Journal of Neuroscience·Yury M Morozov, Tamás F Freund

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Citations

Nov 12, 2010·Journal of Molecular Neuroscience : MN·Vinogran NaidooBen A Bahr
Jun 14, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Russell L CarrMatthew K Ross
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alistair NunnJimmy D Bell
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shivakumar SubbannaBalapal S Basavarajappa
May 6, 2014·European Child & Adolescent Psychiatry·Daniela CalvigioniErik Keimpema
Nov 4, 2015·Brain Sciences·Balapal S Basavarajappa
Mar 22, 2006·Expert Opinion on Investigational Drugs·Ben A BahrAlexandros Makriyannis
Apr 9, 2008·Molecular and Cellular Endocrinology·Tibor HarkanyJan Mulder
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Kent-Olov JonssonChristopher J Fowler
Sep 2, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arnau Busquets-GarciaGiovanni Marsicano
Sep 1, 2018·Journal of Neuropathology and Experimental Neurology·Linda K Friedman, Joann P Wongvravit
Nov 21, 2014·Nature Reviews. Neuroscience·Mauro MaccarroneTibor Harkany
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Jun 18, 2009·Chembiochem : a European Journal of Chemical Biology·Sharon Anavi-Goffer, Jan Mulder
Aug 5, 2005·Journal of Medicinal Chemistry·Didier M Lambert, Christopher J Fowler

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