The spatio-temporal mechanical environment of healthy and injured human cartilage during sustained activity and its role in cartilage damage

Journal of the Mechanical Behavior of Biomedical Materials
Saeed MiraminiBruce S Gardiner

Abstract

Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage. Here we build on the previous study to develop an experimentally validated computational model to simulate mechanical consolidation response of intact and previously injured cartilage under sustained static loading, to develop our understanding of the implications for rates of tissue damage. We see that the type of prior injuries compromise the cartilage function in different ways. Relatively rapid consolidation is predicted for cartilage with a complete meniscectomy and that with a full thickness defect, indicating the inability of cartilage with such injuries to sustain interstitial fluid pressurisation for long periods of time, as does uninjured cartilage. By comparing the consolidation response o...Continue Reading

Citations

Nov 28, 2017·Biomechanics and Modeling in Mechanobiology·Petri TanskaRami K Korhonen
Oct 6, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Umair Farooq, J I Siddique
Aug 20, 2019·Computer Methods and Programs in Biomedicine·Saeed MiraminiLihai Zhang
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Saeed MiraminiLauren E J Thomas-Seale
Mar 7, 2021·Acta Biomaterialia·Carmine PutignanoDaniele Dini
Mar 25, 2021·Computer Methods and Programs in Biomedicine·JinJing LiaoLihai Zhang
Jul 1, 2021·Annals of Biomedical Engineering·Xuanchi LiuLihai Zhang
Nov 23, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Yuqin SunWeiyi Chen

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