The special considerations of gene therapy for mitochondrial diseases.

NPJ Genomic Medicine
Jesse Slone, Taosheng Huang

Abstract

The recent success of gene therapy across multiple clinical trials has inspired a great deal of hope regarding the treatment of previously intractable genetic diseases. This optimism has been extended to the prospect of gene therapy for mitochondrial disorders, which are not only particularly severe but also difficult to treat. However, this hope must be tempered by the reality of the mitochondrial organelle, which possesses specific biological properties that complicate genetic manipulation. In this perspective, we will discuss some of these complicating factors, including the unique pathways used to express and import mitochondrial proteins. We will also present some ways in which these challenges can be overcome by genetic manipulation strategies tailored specifically for mitochondrial diseases.

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Jan 2, 2021·Journal of Clinical Medicine·Francesco GruossoMichelangelo Mancuso
Oct 17, 2020·The Journal of Biological Chemistry·David L ProleNick S Jones
Mar 2, 2021·Molecular Diagnosis & Therapy·Rory J TinkerRobert McFarland

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Methods Mentioned

BETA
gene replacement therapy
PCR
biopsies

Clinical Trials Mentioned

NCT02652780

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