The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus

Nature Reviews. Endocrinology
Jerome Clasadonte, Vincent Prevot

Abstract

Natural fluctuations in physiological conditions require adaptive responses involving rapid and reversible structural and functional changes in the hypothalamic neuroendocrine circuits that control homeostasis. Here, we discuss the data that implicate hypothalamic glia in the control of hypothalamic neuroendocrine circuits, specifically neuron-glia interactions in the regulation of neurosecretion as well as neuronal excitability. Mechanistically, the morphological plasticity displayed by distal processes of astrocytes, pituicytes and tanycytes modifies the geometry and diffusion properties of the extracellular space. These changes alter the relationship between glial cells of the hypothalamus and adjacent neuronal elements, especially at specialized intersections such as synapses and neurohaemal junctions. The structural alterations in turn lead to functional plasticity that alters the release and spread of neurotransmitters, neuromodulators and gliotransmitters, as well as the activity of discrete glial signalling pathways that mediate feedback by peripheral signals to the hypothalamus. An understanding of the contributions of these and other non-neuronal cell types to hypothalamic neuroendocrine function is thus critical both...Continue Reading

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Citations

Mar 17, 2018·Médecine sciences : M/S·Jérôme Clasadonte
Dec 12, 2018·Nature Neuroscience·Cristina García-CáceresMatthias H Tschöp
Jan 31, 2019·Journal of Neuroendocrinology·Esteban RodríguezJuan Luis Blázquez
Jan 20, 2018·Endocrine Reviews·Vincent PrevotJerome Clasadonte
Jul 28, 2019·British Journal of Pharmacology·Konstantina Chachlaki, Vincent Prevot
Jan 31, 2019·Journal of Neurophysiology·Courtney Clyburn, Kirsteen N Browning
Jun 11, 2019·Journal of Neuroendocrinology·Alejandra Freire-RegatilloJulie A Chowen
Jun 24, 2018·Nature Reviews. Neuroscience·Michael H HastingsMarco Brancaccio
Feb 1, 2019·Nature Metabolism·Carmelo QuartaMatthias H Tschöp
May 2, 2019·Frontiers in Endocrinology·Roberto Javier Elizondo-VegaKarina Oyarce
Jan 9, 2019·Frontiers in Immunology·Marina BentivoglioMartin E Rottenberg
Nov 12, 2020·Endocrinology·Lydie NauléUrsula B Kaiser
Mar 2, 2021·Frontiers in Endocrinology·Celia G BarredoFrancisco A Martin
Feb 27, 2021·Nature Metabolism·Carmelo QuartaDaniela Cota
Jan 30, 2021·Endocrinology·Lydie NauléUrsula B Kaiser
May 11, 2020·Domestic Animal Endocrinology·L D PrezottoA T Grazul-Bilska
Apr 6, 2021·Aging and Disease·Maria Rosaria Rizzo, Giuseppe Paolisso
Aug 30, 2020·Molecular and Cellular Endocrinology·Kathryn B Smedlund, Jennifer W Hill
Jun 3, 2021·International Journal of Molecular Sciences·Stéphane LéonCarmelo Quarta
Aug 3, 2021·The Journal of Clinical Investigation·Dongyin Guan, Mitchell A Lazar
Dec 21, 2018·Molecular and Cellular Endocrinology·Lucas Kniess DebarbaLucila Leico Kagohara Elias
Oct 11, 2021·Aging·Gustavo Satoru KajitaniJames Robert Mitchell

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