The specific pattern of retinal nerve fiber layer thinning in Parkinson's disease: a systematic review and meta-analysis.

Journal of Neurology
Lele HuangRuijun Zhang

Abstract

The peripapillar nerve fiber layer (pRNFL) thinning in different retinal quadrants or sectors remains controversy. We conducted a systematic review and meta-analysis on the pattern of pRNFL thinning in Parkinson's disease (PD) patients to provide a biomarker for PD differential diagnosis. We systematically searched PubMed and EMBASE to identify studies comparing pRNFL thickness in PD patients and health controls using spectral domain-optical coherence tomography from inception to April 25, 2020. Random effects mode was used to pool mean difference (μm) of the average thickness of pRNFL and the thickness of pRNFL in four quadrants (superior, inferior, nasal and temporal) and in the subdivisions of superior (superonasal and superotemporal sectors) and inferior quadrants (inferonasal and inferotemporal sectors) between PD patients and health controls. We included 32 studies (33 sets of data) enrolling 2126 PD eyes and 2318 health control eyes. Between the eyes of PD patients and that of health controls, the pooled mean difference (μm) of average pRNFL was - 4.85 (95% CI [- 6.12, - 3.58]); the pooled mean difference (μm) of four quadrants were - 2.30 (95% CI [- 3.32, - 1.28], nasal), - 2.74 (95% CI [- 4.34, - 1.14], temporal), - 5....Continue Reading

References

Nov 22, 1991·Science·D HuangC A Puliafito
Apr 6, 2007·Trends in Neurosciences·Anders Björklund, Stephen B Dunnett
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Neil K ArchibaldDavid J Burn
Apr 20, 2012·PloS One·Philipp AlbrechtAxel Methner
Jun 5, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mohammad RohaniGholamali Shahidi
Aug 18, 2012·Journal of Ophthalmology·Eric M ShrierIvan Bodis-Wollner
Oct 27, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Serkan KirbasMustafa Durmus
Jul 6, 2013·European Journal of Ophthalmology·Aysu SenSenay Asik Nacaroglu
Nov 1, 2013·Retina·Elena Garcia-MartinLuis E Pablo
Nov 28, 2013·The British Journal of Ophthalmology·M SatueE Garcia-Martin
Jan 16, 2014·Investigative Ophthalmology & Visual Science·Elena Garcia-MartinLuis E Pablo
Jan 25, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Beatriz JiménezJavier López del Val
May 3, 2014·Neuroscience Letters·Thomas G BeachUNKNOWN Arizona Parkinson's Disease Consortium
May 13, 2014·Annals of Neurology·Ivan Bodis-WollnerShahnaz Miri
Dec 9, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Esin S SariSitki S Ermis
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Mar 26, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Manpreet KaurVimla Menon
Sep 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Carlos E Mendoza-SantiestebanHoracio Kaufmann
May 27, 2016·Neurology·Andrés Cruz-HerranzUNKNOWN IMSVISUAL consortium
Jul 15, 2016·Brain : a Journal of Neurology·Rimona S WeilHuw R Morris
Oct 18, 2016·Investigative Ophthalmology & Visual Science·Anastasia PilatIrene Gottlob
Feb 17, 2017·Investigative Ophthalmology & Visual Science·Maria SatueElena Garcia-Martin
Jun 10, 2017·Frontiers in Neurology·Carlos E Mendoza-SantiestebanHoracio Kaufmann
Dec 15, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Duygu Gulmez SevimGalip Ertugrul Mirza
Jan 20, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Metin UnluCagatay Karaca
Feb 25, 2018·The Kaohsiung Journal of Medical Sciences·Turkoglu Sule AydinYildiz Serpil
Mar 10, 2018·Journal of Neural Transmission·Femke VisserHenk W Berendse
May 9, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Isabel Ortuño-LizaránNicolás Cuenca
Jun 26, 2018·Parkinsonism & Related Disorders·Juliane MatlachStephan Klebe
May 6, 2019·Parkinsonism & Related Disorders·Asterios ChrysouTeus van Laar
Nov 5, 2019·Acta neurologica Belgica·Betul TugcuHakan Ozdemir

❮ Previous
Next ❯

Citations

Nov 12, 2020·Journal of Neurology·Lele HuangRuijun Zhang
Nov 19, 2020·Acta Neuropathologica Communications·Helen BeardKim M Hemsley
Jul 11, 2021·Journal of Neurology·Xiaoli MaRuijun Zhang
Jul 20, 2021·Journal of Parkinson's Disease·Gregory L BrownEsther M Bowie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
João Paulo CunhaAntónio Castanheira-Dinis
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Esther Maria HoffmannJulia Lamparter
© 2021 Meta ULC. All rights reserved