PMID: 666878Jun 1, 1978Paper

The specific suppression of contact sensitivity

Arthritis and Rheumatism
M I GreeneB Benacerraf


The ability of 2,4,6 trinitrobenzenesulfonic acid (TNBS)-induced regulatory cells to modulate the generation of contact sensitivity (CS) to picryl chloride has been studied. We have confirmed that such suppressor cells can modulate CS and have extended these observations to demonstrate that suppressor factors, liberated by suppressor cells in supernatants, can limit the generation of CS. We have also confirmed that hapten-coupled membrane products can induce tolerance to PCl. The investigation of the properties of the suppressor factors has revealed that they are hapten-specific and bear H2 coded specificities.


Oct 1, 1976·The Journal of Experimental Medicine·H ShikuH F Oettgen
May 1, 1976·British Medical Bulletin·G L Asherson, M Zembala
Jan 1, 1975·Immunological Communications·S FujimotoA H Sehon
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J F MillerJ Gamble
Sep 1, 1976·The Journal of Experimental Medicine·D B MurphyH O McDevitt
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K ImaiM Taniguchi

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