The specificity of antibodies elicited by poly(dG).poly(dC)

Journal of Biomolecular Structure & Dynamics
E M Lafer, B D Stollar

Abstract

Antibodies have been raised to the synthetic DNA polymer poly(dG).poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum.

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Citations

Jan 1, 1989·International Reviews of Immunology·B D Stollar
May 1, 1986·Arthritis and Rheumatism·T J Thomas, R P Messner

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Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.