PMID: 5257961May 1, 1969Paper

The specificity of interferon induction in chick embryo cells by helical RNA

Proceedings of the National Academy of Sciences of the United States of America
C Colby, M J Chamberlin

Abstract

Treatment of chick embryo cells growing in culture with rI:rC and many other RNA-like polymers results in the induction of interferon. DEAE dextran is required to facilitate the uptake of the RNA into the cells. Interferon-inducing activity is found with a variety of double-stranded helical polynucleotides, provided that all the sugar residues are ribose. However, the effectiveness of different active polynucleotides at a given concentration varies considerably. The differences in activity among the various polynucleotides do not appear to reflect differences in the rate or amount of uptake into the cells or in the rate of intracellular breakdown. Thehigh degree of specificity of the induction process is consistent with the existence of a specific intracellular receptor site, which may be a protein.

References

Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·R R Wagner, A S Huang
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A A TytellM R Hilleman
Nov 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J S Krakow, M Karstadt
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·G P LampsonM R Hilleman
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A K FieldM R Hilleman
Feb 1, 1968·Journal of Cellular Physiology·M R Hilleman

❮ Previous
Next ❯

Citations

Jan 1, 1973·The Journal of Membrane Biology·E MayhewR L Juliano
Jan 1, 1975·Archives of Virology·J L SaborioG Koch
Sep 28, 1973·Biochimica Et Biophysica Acta·E De Clercq, B Janik
Jul 6, 1972·The New England Journal of Medicine·S E Grossberg
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H D Robertson, M B Mathews
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C T TengL D Hamilton
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P M PithaJ Pitha
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E De ClercqB Witkop
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M I JohnstonB Witkop
Apr 13, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A Majde
Jan 1, 1984·Journal of Interferon Research·C Svitlik, P I Marcus
Feb 1, 1978·Antimicrobial Agents and Chemotherapy·E C BordenP H Leonhardt
May 1, 1973·Antimicrobial Agents and Chemotherapy·T Sreevalsan
Mar 1, 1976·Antimicrobial Agents and Chemotherapy·E C Borden, P H Leonhardt
Apr 1, 1976·Antimicrobial Agents and Chemotherapy·Y Yamamura, K W Cochran
Sep 3, 2011·Microbiology and Molecular Biology Reviews : MMBR·Denis Gerlier, Douglas S Lyles
Dec 31, 2008·PloS One·Stéphane HausmannDominique Garcin
Jun 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Margaret J Sekellick
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·E D ClercqR G Sommer
Jan 1, 1977·Journal of Invertebrate Pathology·J KalmakoffF J Austin
Feb 28, 1971·Journal of Molecular Biology·E De ClercqT C Merigan
Oct 14, 1972·Journal of Molecular Biology·W A CarterP O Ts'o
Jun 8, 1973·Biochemical and Biophysical Research Communications·P F TorrenceB Witkop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.