PMID: 58456Jan 1, 1976Paper

The specificity of T lymphocyte responses to chemically defined antigens

Transplantation Reviews
C A Janeway

Abstract

A system is described that allows the definition of T cell receptor specificity with some precision. It involves immunization of guinea pigs with hapten coupled to mycobacteria. The T cells of such animals respond to many but not all carriers modified by that hapten. Such T cells recognize neither hapten nor carrier alone, but rather determinants involving both the hapten and the carrier. No evidence for hapten-specific T cells was found. A model of the antigen binding site of the T cell receptor emerged from these experiments. According to this model, the T cell receptor consists of a single site of relatively large extent involving multiple subsites which are of low and roughly equal affinity. Thus, the haptenic group is not immunodominant for T cells as it is for B cells and for anti-hapten antibody. This suggests that the antigen binding receptor on T cells differs in some fundamental way from that on B cells. It is proposed that antigen recognition by T cells is mediated by an immunoglobulin heavy chain variable region that is not paired with an immunoglobulin light chain variable region.

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH N Eisen
Sep 19, 1975·Science·E S Vitetta, J W Uhr
Jan 1, 1975·European Journal of Immunology·C A JanewayW E Paul
Aug 1, 1972·The Journal of Experimental Medicine·N R Klinman
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·U Rutishauser, G M Edelman
Apr 13, 1973·Nature·B Rubin, H Wigzell
Apr 1, 1973·The Journal of Experimental Medicine·M C RaffS De Petris
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Sep 1, 1972·The Journal of Experimental Medicine·J M DavieB Benacerraf
Jan 1, 1967·British Medical Bulletin·J H Humphrey
Mar 1, 1970·The Journal of Experimental Medicine·C Collotti, S Leskowitz
Dec 25, 1970·Science·D C Zoschke, F H Bach
Oct 26, 1967·Biochemical and Biophysical Research Communications·S Shaltiel
May 1, 1962·The Journal of Experimental Medicine·B BENACERRAF, B B LEVINE
Sep 1, 1964·Biochemistry·S UTSUMI, F KARUSH

❮ Previous
Next ❯

Citations

Jan 1, 1984·Developmental and Comparative Immunology·L S WickerW H Hildemann
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Bikoff
Oct 1, 1976·The Journal of Experimental Medicine·T G RehnG M Shearer
Jun 1, 1980·The Journal of Experimental Medicine·L A Sherman
Dec 1, 1980·The Journal of Experimental Medicine·M KronenbergJ D Watson
Jan 1, 1976·Scandinavian Journal of Immunology·C A JanewayH Binz
Oct 1, 1984·Immunological Reviews·J Klein
Jan 1, 1978·Scandinavian Journal of Immunology·J J Burckhardt
Dec 14, 1979·Molecular and Cellular Biochemistry·A B Stavitsky, A A Gerblich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.