The Speckle Tracking Imaging for the Assessment of Cardiac Resynchronization Therapy (START) study

Circulation Journal : Official Journal of the Japanese Circulation Society
Takeshi MaruoKazutaka Aonuma

Abstract

We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. METHODS AND RESULTS: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (Tmax). In segments with multiple peaks on the time-strain curves, time to the first peak (Tfirst) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. Tfirst-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78-25.6). In addition, Tfirst-SD of CS was associated with t...Continue Reading

References

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Citations

Jan 12, 2016·Revista Española De Cardiología·Teresa López-FernándezJoaquín Barba-Cosials
Nov 13, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yi-Hsin ChanWan-Jing Ho
Mar 5, 2016·Journal of Echocardiography·Kaoru DohiMasaaki Ito
Jul 5, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chuan QinMing-Xing Xie
May 24, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Hanan KhamisDan Adam
Oct 13, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato Fukunaga, Kenji Ando
Oct 30, 2016·Journal of the American Heart Association·Yoshihiro SeoKazutaka Aonuma
Jul 20, 2019·Pacing and Clinical Electrophysiology : PACE·Aya FujiiToyoaki Murohara
Dec 15, 2015·American Journal of Therapeutics·André Miguel Ramos Travessa, Luiz Filipe de Menezes Falcão
Jan 16, 2016·Journal of Echocardiography·Hidekazu Tanaka, Ken-Ichi Hirata

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