The Spectrum of Autoimmune Thyroid Disease in the Short to Medium Term Following Interferon-alpha Therapy for Chronic Hepatitis C.

International Journal of Endocrinology
Huy A Tran, Glenn Em Reeves

Abstract

Autoimmune thyroid diseases are common manifestations of hepatitis C infection, exacerbated by interferon-based treatment. However, the occurrence and pattern of thyroid disease in the short/medium term following the completion of IFN-based therapy is relatively unknown and there are very few previous reports regarding the specific spectrum of autoimmune thyroid disease that may follow such therapy. We hereby report 3 cases which demonstrate the range of thyroid diseases that may occur following interferon therapy. The hypothesis advanced is that in the pathogenesis of these conditions there must be both triggering and sustaining mechanisms as thyroid diseases occur well outside the immediate effect window of pegylated interferon. This paper suggests the need to continue thyroid surveillance in IFN-treated HCV patients following the completion of therapy, perhaps for the first 6 months.

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Citations

Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Zohreh Jadali
Nov 7, 2014·International Journal of Endocrinology·Poupak FallahiAlessandro Antonelli
Feb 1, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Z A GoncharovaV A Megeryan

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