The spectrum of clinicopathological features in pure autonomic neuropathy.

Journal of Neurology
Haruki KoikeGen Sobue

Abstract

We assessed the clinicopathological features of nine patients with pure autonomic neuropathy, that is, neuropathy without sensory or motor deficits. The duration from symptom onset to diagnosis ranged from 1 month to 13 years. Of eight patients in whom serum antiganglionic acetylcholine receptor antibody was determined, four were positive. All patients who tested positive for this antibody manifested widespread autonomic dysfunction, with the exception of one patient who only experienced orthostatic hypotension. However, patients who were negative for the antiganglionic acetylcholine receptor antibody presented with partial autonomic failure. One of these patients had diffuse parasympathetic failure and generalized hypohidrosis but no orthostatic hypotension, which is clinically compatible with postganglionic cholinergic dysautonomia. Electron microscopic examination revealed a variable degree of reduction in unmyelinated fibers. Compared with normal controls, the patients had a significantly increased density of collagen pockets (p < 0.05). Additionally, the percentage of Schwann cell subunits with axons (out of the total number of Schwann cell subunits associated with unmyelinated fibers) was significantly decreased (p < 0.01...Continue Reading

References

Sep 1, 1975·Brain : a Journal of Neurology·F BehseG G Knappeis
Feb 1, 1991·Brain : a Journal of Neurology·T KandaH Tanabe
Feb 1, 1989·Brain : a Journal of Neurology·G SobueA Takahashi
Dec 1, 1985·Brain : a Journal of Neurology·J M Jacobs, S Love
Jun 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·E van IngelghemM Lammens
Mar 4, 1998·Annals of Neurology·T KandaH Mizusawa
Aug 24, 1999·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Y NiimiA Takahashi
Aug 23, 2000·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·N HishikawaG Sobue
Sep 21, 2000·The New England Journal of Medicine·S VerninoV A Lennon
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H WatanabeG Sobue
May 27, 2003·Muscle & Nerve·Phillip A LowGuillermo Suarez
May 30, 2003·Journal of Neurophysiology·Steven VerninoVanda A Lennon
Jun 5, 2003·Annals of Neurology·Caroline M KleinPhillip A Low
Aug 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven VerninoVanda A Lennon
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·N MabuchiG Sobue
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H KoikeG Sobue
Nov 8, 2005·Lancet·Richard A C Hughes, David R Cornblath
Sep 14, 2006·Current Opinion in Neurology·Haruki Koike, Gen Sobue
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Haruki KoikeGen Sobue
Feb 13, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Norio HoriGen Sobue
May 14, 2008·Neurology·Steven VerninoPhillip A Low
Nov 26, 2008·Autonomic Neuroscience : Basic & Clinical·S K BakerS Vernino
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Paola Sandroni, Phillip A Low
Jan 22, 2009·Autonomic Neuroscience : Basic & Clinical·David S GoldsteinRichard Imrich
Jun 23, 2009·Autonomic Neuroscience : Basic & Clinical·Kurt KimpinskiPhillip A Low
Jan 5, 2010·Internal Medicine·Naoko MatsuiRyuji Kaji
May 13, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Haruki KoikeGen Sobue
Jul 17, 2010·Current Opinion in Neurology·Nicole Winston, Steven Vernino
Aug 26, 2010·Brain : a Journal of Neurology·Haruki KoikeGen Sobue
Sep 15, 2010·Pediatric Neurology·Philip R FischerSatish R Raj
Sep 22, 2010·Brain : a Journal of Neurology·Haruki Koike, Gen Sobue
Jan 7, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Pantelis MaiovisDimitris Karacostas
Jul 30, 2011·Current Opinion in Neurology·Haruki KoikeGen Sobue

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Citations

Jun 19, 2013·Journal of Neurology·Pierre LozeronNathalie Kubis
Jul 16, 2013·Autoimmune Diseases·Anna MazzeoGiuseppe Vita
Jul 30, 2014·Nature Reviews. Neurology·Benjamin R WakerleyUNKNOWN GBS Classification Group
Dec 3, 2013·Rinshō shinkeigaku = Clinical neurology·Haruki Koike, Gen Sobue
Apr 20, 2013·Autonomic Neuroscience : Basic & Clinical·Ken OhyamaGen Sobue
Jul 23, 2016·Neurologic Clinics·Inna Kleyman, Louis H Weimer
Mar 25, 2014·Journal of the American Animal Hospital Association·Joseph W Spoo, G Diane Shelton
Oct 10, 2014·Continuum : Lifelong Learning in Neurology·Valeria Iodice, Paola Sandroni
May 17, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Elisabeth P Golden, Steven Vernino
Jan 1, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Belén RodriguezWerner J Z'Graggen

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