Apr 24, 2014

The spectrum of cognitive impairment in Lewy body diseases

Movement Disorders : Official Journal of the Movement Disorder Society
Jennifer G GoldmanJames E Galvin

Abstract

Cognitive impairment represents an important and often defining component of the clinical syndromes of Lewy body disorders: Parkinson's disease and dementia with Lewy bodies. The spectrum of cognitive deficits in these Lewy body diseases encompasses a broad range of clinical features, severity of impairment, and timing of presentation. It is now recognized that cognitive dysfunction occurs not only in more advanced Parkinson's disease but also in early, untreated patients and even in those patients with pre-motor syndromes, such as rapid eye movement behavior disorder and hyposmia. In recent years, the concept of mild cognitive impairment as a transitional or pre-dementia state in Parkinson's disease has emerged. This has led to much research regarding the diagnosis, prognosis, and underlying neurobiology of mild cognitive impairment in Parkinson's disease, but has also raised questions regarding the usefulness of this concept and its application in clinical and research settings. In addition, the conundrum of whether Parkinson's disease dementia and dementia with Lewy bodies represent the same or different entities remains unresolved. Although these disorders overlap in many aspects of their presentations and pathophysiology, ...Continue Reading

  • References125
  • Citations40

Citations

Mentioned in this Paper

Senile Paranoid Dementia
Supranuclear Palsy, Progressive,1, Atypical
Mental Disorders
Neurobiology
Cognition Disorders
Lewy Bodies
Mild Cognitive Disorder
Parkinson Disease
Physiopathological
Lewy Body Disease

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