The spectrum of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation: US survey assessing symptoms, care seeking, and disease burden

The American Journal of Gastroenterology
Joel J HeidelbaughWilliam D Chey

Abstract

The irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) are associated with substantial symptom and disease burden. Although typically classified as distinct diseases, symptoms frequently overlap. The objective of this study was to characterize symptom and disease burden in IBS-C and CIC sufferers and examine a subset of CIC sufferers with abdominal symptoms. In a US population-based survey, respondents meeting the Rome III criteria for IBS-C or CIC rated symptom frequency and bothersomeness, missed work and disrupted productivity, and degree of obtaining and satisfaction with physician care. CIC respondents were analyzed in two subgroups: those with abdominal symptoms ≥once weekly (CIC-A) and those without (CIC-NA). Of the 10,030 respondents, 328 met the criteria for IBS-C and 552 for CIC (363 CIC-A; 189 CIC-NA). All symptoms were significantly more frequent in IBS-C vs. CIC respondents (P<0.0001). Constipation was extremely/very bothersome in 72% of IBS-C respondents, 62% of CIC-A, and 40% of CIC-NA (P<0.01 all pairs). All 11 other measured symptoms were significantly more bothersome in IBS-C and CIC-A vs. CIC-NA respondents. In IBS-C vs. CIC-A, abdominal discomfort, bloating, strainin...Continue Reading

References

Sep 13, 2000·Gastroenterology·I M GralnekE A Mayer
May 29, 2002·Alimentary Pharmacology & Therapeutics·H B El-SeragD Bjorkman
Mar 26, 2004·Gastroentérologie Clinique Et Biologique·Henri DamonFrançois Mion
Sep 15, 2004·Archives of Internal Medicine·Brennan M R SpiegelBruce Naliboff
Jul 27, 2005·Current Gastroenterology Reports·Christine L Frissora, Kenneth L Koch
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·C GálvezJ Ponce
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·J F Johanson, J Kralstein
Jul 21, 2009·Current Gastroenterology Reports·Brennan M R Spiegel
May 27, 2010·The American Journal of Gastroenterology·Reuben K WongWilliam E Whitehead
May 25, 2011·The American Journal of Gastroenterology·Nicole C Suares, Alexander C Ford
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
Oct 26, 2013·Journal of Managed Care Pharmacy : JMCP·Dave NellesenRobyn T Carson
Oct 26, 2013·Gastroenterology Research and Practice·Pia Møller FaaborgKlaus Krogh
Jun 5, 2014·The American Journal of Gastroenterology·Filippo Cremonini, Anthony Lembo
Aug 6, 2014·The American Journal of Gastroenterology·Alexander C FordEamonn M M Quigley

❮ Previous
Next ❯

Citations

Dec 3, 2015·Expert Opinion on Pharmacotherapy·Eamonn M M Quigley, Leila Neshatian
Feb 18, 2016·Gastroenterology Research and Practice·Paul EnckJuliane Schwille-Kiuntke
Aug 1, 2015·Clinical and Translational Gastroenterology·Jason BakerWilliam D Chey
May 5, 2016·Gastroenterology·Olafur S PalssonYunsheng Yang
Jun 9, 2016·Journal of Neurogastroenterology and Motility·Satish S C Rao, Tanisa Patcharatrakul
Nov 9, 2016·Gastroenterology Research and Practice·Paul EnckJuliane Schwille-Kiuntke
Jul 13, 2016·United European Gastroenterology Journal·Paul EnckJuliane Schwille-Kiuntke
Jul 13, 2016·United European Gastroenterology Journal·Nimish VakilSteve Miller
Jul 13, 2016·Journal of Pediatric Gastroenterology and Nutrition·Shaman RajindrajithMarc A Benninga
Aug 4, 2016·BMJ Open Gastroenterology·Irene SonuJerry D Gardner
Jan 7, 2017·Journal of Clinical Gastroenterology·Kyle StallerAshwin N Ananthakrishnan
Nov 18, 2017·Therapeutic Advances in Gastroenterology·Michael DeMiccoPatrick Griffin
Dec 15, 2017·Nature Reviews. Disease Primers·Michael CamilleriLin Chang
May 31, 2018·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Claire Jungyoun HanMargaret M Heitkemper
Aug 21, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hui ZhengJian-Qiao Fang
Mar 23, 2018·Gut·Scott A Waldman, Michael Camilleri
Oct 3, 2018·Current Medical Research and Opinion·Charles F BarishPatrick H Griffin
Jul 19, 2019·Clinical and Translational Gastroenterology·Scott A WaldmanPatrick Griffin
Oct 9, 2019·Journal of Clinical Gastroenterology·Ya JiangLin Lin
Mar 31, 2017·Pharmacology Research & Perspectives·Andrea BrancaleGary S Jacob
Jan 25, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jasper PannemansJan Tack
Mar 19, 2020·Digestive Diseases and Sciences·Charles BarishJonathan Rosenberg
Aug 18, 2017·Orphanet Journal of Rare Diseases·Cecilie EjerskovAnnette Haagerup
Oct 27, 2018·F1000Research·David O Prichard, Adil E Bharucha
Nov 8, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ayesha ShahGerald Holtmann
Jun 27, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Omesh GoyalAjit Sood
Aug 9, 2020·Clinical and Experimental Gastroenterology·Arpita NagRenu M Vekaria
May 10, 2018·World Journal of Gastroenterology : WJG·Illona-Marie BouleteKunwar Shailubhai
Jun 27, 2018·Therapeutic Advances in Gastroenterology·Satish S C Rao
Feb 8, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Omar F AlButayshFahad S Alharbi
Jun 5, 2020·BMC Gastroenterology·Sanne J VerkuijlPaul M A Broens
Dec 4, 2016·International Journal of Colorectal Disease·Rob J MeindsPaul M A Broens

❮ Previous
Next ❯

Software Mentioned

Quantum

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.