The spectrum of long-term cognitive and functional outcome after hemispherectomy in childhood

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Monique M J van SchooneveldAag Jennekens-Schinkel

Abstract

To evaluate cognition, behavior, daily functioning and health-related quality of life (HrQoL) five years to more than a decade after hemispherectomy (HE) in childhood. This countrywide Dutch cohort study of 31 patients, who underwent HE between 1994 and 2009, included a semi-structured interview with parents, an assessment of cognition, and screening of behavioral problems and HrQoL. Twenty-two school-age children and young adults [median age 13.8 years (0.5 at epilepsy onset, 5.3 at HE)] were assessed with age-appropriate cognitive tests. IQ ranged from 45 to 82 (median 61). Despite performing below mean norm scores, these participants could learn and remember, sustain attention, inhibit irrelevant responses, read and write. Nine more children [median age 9.7 years (0.25 at epilepsy onset, 1.4 at HE)] were so mentally retarded that age-appropriate testing was impossible. This group was almost totally dependent on others in daily activities, had the highest proportion of pre-existing contralateral MRI-abnormalities and after HE the highest rates of seizure recurrence and behavioral problems. Parents in both groups rated HrQoL surprisingly positively (mean VAS-score 72.5), with a scarce low rating (40). All parents reported prob...Continue Reading

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Citations

Dec 7, 2017·The Journal of Nervous and Mental Disease·Michael NahmBruce Greyson
Mar 23, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alessandra MolettoPiernanda Vigliano
Sep 4, 2020·Epilepsy & Behavior : E&B·Tamara P TavaresMary Lou Smith
Apr 29, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alejandro J LopezBenjamin C Kennedy
Aug 17, 2021·Journal of Epilepsy Research·Al Khateeb MashaelRazack Raidah Ayesha
Mar 22, 2020·Epilepsy & Behavior : E&B·Suenia Timotheo Figueiredo LealAna Paula Andrada Hamad

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