The spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
WeiGe WangXiaoqiu Li

Abstract

To retrospectively investigate the clinicopathologic spectrum of primary mucosal CD30-positive T-cell lymphoproliferative disorders (PTCLDs) of the head and neck. Archives of PTCLDs primarily arising in head and neck mucosa were reviewed. Immunostaining of CD20, CD3, CD4, CD8, CD30, CD56, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA), cytotoxic molecules (TIA-1, granzyme B, or perforin), and Ki67; in situ hybridization for Epstein-Barr virus; and T-cell receptor gene rearrangement analysis were performed. Fourteen cases of primary mucosal anaplastic large cell lymphoma (M-ALCL) were identified, and no lymphomatoid papulosis (LyP) cases were found. All cases demonstrated atypical mononuclear neoplastic cells with diverse histology and cytomorphology. The typical immunophenotype of neoplastic cells was CD3-positive, CD4-positive, CD8-negative, CD30-positive, ALK-negative, and cytotoxic molecules-positive. Infiltration of inflammatory cells was common. All cases presented an indolent course, regardless of therapy. PTCLDs of the head and neck provisionally included M-ALCL alone.

References

Apr 1, 1995·The American Journal of Surgical Pathology·K P MannH Ratech
Jun 1, 1997·The British Journal of Oral & Maxillofacial Surgery·A ChanduA M Corrigan
Oct 28, 1998·The American Journal of Dermatopathology·N KatoH Hisai
Nov 14, 1998·Oral Oncology·C S ChimL Raymond
Aug 11, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J SciubbaJ Fantasia
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Apr 5, 2008·International Journal of Surgical Pathology·Monica AgarwalS Sankar Banerjee
Jul 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·N ErõsS Kárpáti
Jul 29, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Naoyuki MatsumotoKazuo Komiyama
Jul 8, 2010·Australian Dental Journal·A VillaF Villa
Jul 16, 2010·The Journal of Dermatology·Shiori ItohYuji Horiguchi
Oct 5, 2010·Haematologica·Laurence de Leval, Philippe Gaulard
Apr 6, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·M B Abdel-NaserC C Zouboulis
Mar 6, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew P SciallisAndrew L Feldman
Sep 4, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Anupama GrandhiPaul D Freedman
May 8, 2013·The American Journal of Surgical Pathology·Laszlo J KaraiAndrew L Feldman

❮ Previous
Next ❯

Citations

Jun 25, 2015·Leukemia & Lymphoma·Yu Zeng, Andrew L Feldman
Nov 20, 2015·Expert Review of Hematology·Nabila Bennani-BaitiAndrew L Feldman
Jun 30, 2015·Human Pathology·Beenu ThakralL Jeffrey Medeiros
Dec 3, 2014·Advances in Anatomic Pathology·Xiaoming Xing, Andrew L Feldman
May 23, 2020·Head and Neck Pathology·Bruno Augusto Benevenuto de AndradeMário José Romañach
Feb 20, 2019·Virchows Archiv : an International Journal of Pathology·José CabeçadasAlfio Ferlito
Nov 30, 2019·Virchows Archiv : an International Journal of Pathology·Ilske OschliesJohn R Goodlad
Mar 10, 2021·American Journal of Clinical Pathology·Catalina Amador, Andrew L Feldman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2021 Meta ULC. All rights reserved