The spectrum of thrombin in acute coronary syndromes

Thrombosis Research
Smith Giri, Lisa K Jennings

Abstract

The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical trial results that have compared the use of parenteral or oral anticoagulants versus or in combination with anti-platelet agents have forced a reexamination of the importance of thrombin activity in influencing patient outcomes, particularly in the area of secondary prevention. The debate of the need to include oral anticoagulation as a concomitant or replacement therapy to an antiplatelet regimen as a means to improve patient outcomes requires further examination and larger prospective clinical trials.

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Citations

Feb 28, 2017·Nature Reviews. Nephrology·Kristina N EkdahlBo Nilsson
Oct 22, 2016·Therapeutic Advances in Cardiovascular Disease·April RobinsonJanine Douglas
Feb 20, 2016·The Journal of Trauma and Acute Care Surgery·Matthew T RamseyLisa K Jennings
Jan 14, 2020·Journal of Agricultural and Food Chemistry·Takashi HosonoTaiichiro Seki

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