The sperm deformity index: a reliable predictor of the outcome of oocyte fertilization in vitro

Fertility and Sterility
Nabil AzizI Lewis-Jones

Abstract

To evaluate a novel expression of sperm morphological parameters, the sperm deformity index, as a predictor of fertilization in vitro. Prospective blind clinical trial. Academic tertiary referral center. Detailed sperm morphological assessment applying strict morphological criteria and a multiple entry technique for an unselected male population undergoing IVF. The sperm deformity index, defined as the average number of deformities per sperm assessed, was calculated. One hundred fifty-eight patients undergoing IVF treatment. Females with conditions negatively influencing fertilization were excluded. Fertilization rates and pregnancy. Seventy-three percent of patients achieved fertilization. Patients achieving fertilization had a significantly higher median proportion of normal forms and a significantly lower median sperm deformity index than the nonfertilizers. The receiver operator characteristic (ROC) curves identified cutoff points that maximized the sum of sensitivity and specificity at sperm deformity index 1.6 and normal forms 4%. The sperm deformity index had a greater sensitivity (96%), specificity (72%), positive predictive value (90%), and negative predictive value (86%) than the proportion of normal sperm morphology ...Continue Reading

Citations

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