PMID: 7544586Nov 1, 1994Paper

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
R N KolesnickZ Fuks

Abstract

Recent evidence suggests that tumor necrosis factor alpha, Fas, and ionizing radiation employ the sphingomyelin pathway to trigger apoptosis. The sphingomyelin pathway is initiated by hydrolysis of plasma membrane sphingomyelin to generate ceramide via a sphingomyelinase. Ceramide serves as a second messenger stimulating a cascade of kinases and transcription factors that activate a final common pathway of programmed cell death. The extent to which this signaling system is used in apoptosis induced by other toxic modalities is not known, but accumulating evidence suggests that it is a commonly employed pathway that could be exploited therapeutically.

Citations

Jan 24, 2009·Applied Biochemistry and Biotechnology·F XuK J L Burg
Jul 8, 2010·Neuromolecular Medicine·Arundhati Jana, Kalipada Pahan
Aug 1, 2002·Life Sciences·Xiaohua TanDianyuan Zhou
Feb 18, 1999·Toxicology Letters·P H Krammer
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Benedetta CinqueM Grazia Cifone
Feb 18, 1999·Current Opinion in Chemical Biology·E C JonathanW G McKenna
Dec 25, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ayman E M MahdyXiang Liu
Dec 31, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Satish GowdaRaj Wadgaonkar
Nov 20, 2008·Journal of Lipid Research·Nana Bartke, Yusuf A Hannun
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HunotE C Hirsch
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·P XiaM A Vadas
Sep 6, 2011·Annual Review of Physiology·Natasha C Lucki, Marion B Sewer
Sep 8, 2015·Colloids and Surfaces. B, Biointerfaces·Pasupathi SundaramoorthyHwan Mook Kim
Nov 21, 2008·Fertility and Sterility·Agnieszka ChrobakMałgorzata Jerzak
Aug 8, 2015·The Breast : Official Journal of the European Society of Mastology·John YarnoldJudith M Bliss
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Timothy M Pawlik, Khandan Keyomarsi
Apr 15, 2011·Journal of Lipids·Wei-Ching HuangChiou-Feng Lin
Oct 26, 2010·Progress in Lipid Research·Gauri A Patwardhan, Yong-Yu Liu
Mar 31, 2000·Experimental Cell Research·H Walczak, P H Krammer
Jun 1, 1997·Clinical Immunology and Immunopathology·M A MusciG A Koretzky
Feb 9, 2010·Steroids·Natasha C Lucki, Marion B Sewer
Mar 30, 1999·Experimental Cell Research·B ZhivotovskyS Orrenius
Apr 9, 2015·Frontiers in Medicine·Jean-Pierre PougetIsabelle Navarro-Teulon
May 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Hyeon LeeTack-Joong Kim
Aug 3, 2016·Medicinal Research Reviews·Dominik Vogt, Holger Stark
Sep 18, 2003·Journal of Lipid Research·Ryan J Perry, Neale D Ridgway
Sep 9, 2011·Therapeutic Advances in Respiratory Disease·Yang Yang, Stefan Uhlig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis