The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function.

Journal of Lipid Research
Binks W WattenbergDaniel M Raben

Abstract

The sphingosine and diacylglycerol kinases form a superfamily of structurally related lipid signaling kinases. One of the striking features of these kinases is that although they are clearly involved in agonist-mediated signaling, this signaling is accomplished with only a moderate (and sometimes no) increase in the enzymatic activity of the enzymes. Here, we summarize findings that indicate that signaling by these kinases is strongly dependent on their localization to specific intracellular sites rather than on increases in enzyme activity. Both the substrates and products of these enzymes are bioactive lipids. Moreover, many of the metabolic enzymes that act on these lipids are found in specific organelles. Therefore, changes in the membrane localization of these signaling kinases have profound effects not only on the production of signaling lipid phosphates but also on the metabolism of the upstream signaling lipids.

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·I MasaiY Hotta
Jan 1, 1992·Methods in Enzymology·R N Lemaitre, J A Glomset
Jul 1, 1991·The Journal of Cell Biology·H ZhangS Spiegel
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I N Maruyama, S Brenner
Jul 1, 1994·The Journal of Cell Biology·A M Shenoy-ScariaD M Lublin
May 1, 1994·Trends in Biochemical Sciences·D Bossemeyer
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M ValverdeE Rozengurt
Mar 15, 1996·Journal of Cellular Biochemistry·A OliveraS Spiegel
Apr 1, 1996·Protein Science : a Publication of the Protein Society·C D Thanos, J U Bowie
Jul 25, 1998·The Journal of Biological Chemistry·M M NagiecR C Dickson
Sep 3, 1998·The Journal of Biological Chemistry·T KohamaS Spiegel
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·P XiaM A Vadas
Feb 6, 1999·The Journal of Biological Chemistry·R AlemanyK H Jakobs
Apr 3, 1999·The Journal of Biological Chemistry·R A AndersonJ C Loijens
Apr 17, 1999·The Journal of Biological Chemistry·M K Topham, S M Prescott
Jun 8, 1999·Chemistry and Physics of Lipids·W J van Blitterswijk, B Houssa
Nov 24, 1999·FEBS Letters·D Meyer zu HeringdorfK H Jakobs
May 10, 2000·FEBS Letters·V E NavaS Spiegel
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M MandalaS Spiegel
Mar 10, 2001·European Journal of Pharmacology·D Meyer zu HeringdorfK H Jakobs
Apr 4, 2001·The Journal of Cell Biology·M A SanjuánI Mérida
Apr 20, 2001·The Journal of Biological Chemistry·L BregoliD M Raben
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H M RosenfeldtS Spiegel
Jan 5, 2002·The Journal of Biological Chemistry·Pu XiaMathew A Vadas

❮ Previous
Next ❯

Citations

Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Feb 19, 2011·The Journal of Biological Chemistry·Liang GuoXuemin Wang
Jul 27, 2012·The Journal of Biological Chemistry·Christopher R GaultLina M Obeid
Oct 15, 2008·The Journal of Biological Chemistry·Renae K BarrStuart M Pitson
Oct 2, 2013·BMC Developmental Biology·Shuji UedaYasuhito Shirai
Jan 27, 2010·Journal of Lipid Research·Nora P RotsteinO Lorena German
Apr 5, 2008·Journal of Lipid Research·Deborah A Lebman, Sarah Spiegel
Dec 11, 2008·Journal of Lipid Research·Daniel M Raben, Binks W Wattenberg
May 4, 2011·World Journal of Biological Chemistry·Binks W Wattenberg
Jan 24, 2014·Neurochemical Research·Magdalena GassowskaJoanna B Strosznajder
Apr 10, 2014·Biochimica Et Biophysica Acta·Doris HöglingerCarsten Schultz
Jan 24, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Regina AlemanyDagmar Meyer Zu Heringdorf
Sep 6, 2011·Annual Review of Physiology·Natasha C Lucki, Marion B Sewer
Mar 23, 2011·Nature Chemical Biology·Sandra J UllrichClemens Glaubitz
Feb 17, 2007·Expert Opinion on Investigational Drugs·Thomas BaumrukerVolker Brinkmann
Jun 24, 2008·Endothelium : Journal of Endothelial Cell Research·Vidya Limaye
Aug 26, 2011·Critical Reviews in Biochemistry and Molecular Biology·Deanna Siow, Binks Wattenberg
Apr 30, 2015·Critical Reviews in Biochemistry and Molecular Biology·Michael J Pulkoski-GrossLina M Obeid
Jul 18, 2012·Biochimica Et Biophysica Acta·Huasheng Chan, Stuart M Pitson
Nov 10, 2011·Progress in Lipid Research·Esther RincónIsabel Mérida
Sep 28, 2010·Trends in Biochemical Sciences·Stuart M Pitson
Sep 11, 2010·European Journal of Pharmacology·J Adolfo García-SáinzLuz del Carmen Medina
Jul 6, 2010·Prostaglandins & Other Lipid Mediators·Piotr ZabielskiJan Górski
Oct 6, 2009·Experimental Cell Research·Priya SrideviStephen Alexander
Oct 8, 2009·Prostaglandins & Other Lipid Mediators·Rochelle P CoelhoCarmen Sato-Bigbee
Jun 19, 2009·Advances in Enzyme Regulation·Nigel J PyneSusan Pyne
Oct 16, 2009·Biochimica Et Biophysica Acta·Michael ter BraakDagmar Meyer zu Heringdorf
Nov 10, 2007·Prostaglandins & Other Lipid Mediators·Alice PébayStuart M Pitson
Sep 22, 2007·Analytical Biochemistry·Deanna L Siow, Binks W Wattenberg
May 28, 2009·Journal of Cellular Physiology·Becky Tu-Sekine, Daniel M Raben
Aug 8, 2015·Chemistry and Physics of Lipids·Francesca CingolaniJosefina Casas
Mar 26, 2013·British Journal of Haematology·Craig T Wallington-BeddoeLinda J Bendall
Mar 30, 2016·Trends in Biochemical Sciences·David R AdamsNigel J Pyne
Aug 20, 2009·Archives of Biochemistry and Biophysics·S J PasquaréN M Giusto

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

© 2021 Meta ULC. All rights reserved