The spider toxin Phα1β recombinant possesses strong analgesic activity

Toxicon : Official Journal of the International Society on Toxinology
Flávia Karine RigoMarcus Vinicius Gomez

Abstract

The native Phα1β - a Voltage-Gated Calcium Channel (VGCC) blocker - and its Recombinant Version - were both tested in rodent pain models with an intraplantar injections of capsaicin or formalin, a chronic constriction injury, and melanoma cancer related pain. The formalin nociceptive behaviour in the neurogenic phase was not affected by the toxin pre-treatments, while in the inflammatory phase, Phα1β and the Recombinant form caused a significant reduction. The nociception that was triggered by capsaicin, an agonist of the TRPV1 vanilloid receptor, was totally blocked by 100 pmol/site, i.t. of Phα1β or the recombinant version. For the neuropathic pain that was induced by a chronic constriction injury of the sciatic nerve, Phα1β and its Recombinant reduced the allodynia that was induced by the CCI procedure in the rats and the hypersensitivity lasted for 4 h. Fourteen days after the inoculation of the B16-F10 melanoma cells in the mice, a marked hyperalgesia was induced in the melanoma cancer pain model. Phα1β and the Recombinant form reduced the hyperalgesia with a full reversion at 100 pmol/site i.t. The inhibitory effects of the nociception that was induced by native Phα1β and the Recombinant in the studied pain models were no...Continue Reading

Citations

Nov 1, 2018·Current Medicinal Chemistry·Xinwang YangEng-Ang Ling
Aug 28, 2020·Frontiers in Pharmacology·Karla de Castro Figueiredo BordonEliane Candiani Arantes
Mar 1, 2019·Toxins·Yossi MaatufAvi Priel
Nov 19, 2018·Basic & Clinical Pharmacology & Toxicology·Alessandra Hubner de SouzaJaqueline Nascimento Picada
May 14, 2020·Pharmacological Reports : PR·Emanuelle Sistherenn CaminskiAlessandra Hubner de Souza
May 5, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Flavia Karine RigoMarcus Vinicius Gomez
Dec 18, 2020·Neuropeptides·Julliane V Joviano-SantosCristina Guatimosim
Mar 24, 2021·Toxicon : Official Journal of the International Society on Toxinology·Mariana Peluci Garcia MendesMarcus Vinicius Gomez
Apr 18, 2018·Journal of the American Society for Mass Spectrometry·Kelly L WormwoodCostel C Darie
Jul 16, 2020·Toxicon : Official Journal of the International Society on Toxinology·Pedro Santana Sales LauriaLuciana Lyra Casais-E-Silva
Oct 11, 2020·Toxicon : Official Journal of the International Society on Toxinology·Raquel TonelloJuliano Ferreira

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