PMID: 15329601Aug 27, 2004Paper

The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine

Anesthesiology
Uta Muth-SelbachHanns Ulrich Zeilhofer

Abstract

The neuropeptide nocistatin (NST) has been implicated in the modulation of nociceptive responses in the spinal cord. Depending on the dose, both pronociceptive and antinociceptive effects have repeatedly been reported. The pronociceptive effect is most likely attributable to inhibition of synaptic glycine and gamma-aminobutyric acid release and a subsequent reduction in the activation of inhibitory glycine and gamma-aminobutyric acid receptors, but the mechanisms of its antinociceptive action have hitherto remained elusive. It has recently been demonstrated that synaptically released glycine contributes to N-methyl-D-aspartate receptor activation. The authors therefore investigated whether a reduction in glycine release might also account for the antinociceptive action of NST in neuropathic rats. The authors analyzed the effects of spinally applied NST in the chronic constriction injury model of neuropathic pain. NST was injected intrathecally from nanomolar to picomolar doses and its effects on thermal paw withdrawal latencies were monitored. Furthermore, we tested whether D-serine (100 microg per rat), a full agonist at the glycine binding site of the N-methyl-D-aspartate receptor, would interfere with the effects of NST. At ...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A KempG N Woodruff
Apr 13, 1999·Trends in Neurosciences·M KoltzenburgS B McMahon
Feb 13, 2001·Trends in Neurosciences·D E BarañanoS H Snyder
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Makoto InoueHiroshi Ueda
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hanns Ulrich Zeilhofer, Girolamo Calò
Jun 28, 2003·Science·Seifollah AhmadiHanns Ulrich Zeilhofer

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Citations

Apr 27, 2011·Amino Acids·Mendel Friedman, Carol E Levin
Apr 2, 2011·Regional Anesthesia and Pain Medicine·Henning HermannsInge Bauer
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Aug 31, 2006·Neurochemical Research·Rama SethuramanShinro Tachibana
Apr 28, 2009·European Journal of Pharmacology·Uta Muth-SelbachPeter Lipfert
Mar 21, 2006·Biochemical and Biophysical Research Communications·Ji-Dong GuoZhi-Qi Zhao
Mar 15, 2006·Brain Research Bulletin·Rainer FreynhagenUta Muth-Selbach
Jul 1, 2016·Channels·Luca AvenaliManuela Schmidt
Jun 26, 2007·Clinical Chemistry·Rama SethuramanShinro Tachibana

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