The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results

Radiology
Joseph C J BotFrederik Barkhof

Abstract

To correlate quantitative magnetic resonance (MR) imaging data (ie, relaxation times and magnetization transfer ratios [MTRs]) with histopathologic findings of demyelination and axonal disease in cervical spinal cord specimens from patients with multiple sclerosis (MS) and control subjects. Formaldehyde-fixed cervical spinal cord specimens from 11 patients with MS-three men and eight women (mean age at death, 66 years +/- 11.3 [standard deviation])-and two female control subjects without neurologic disease (83 and 41 years of age at death) were examined at 4.7 T. Relaxation time measurements and MTR mapping were performed. Analyses included the whole cord area and region-of-interest measurements. Histopathologic analyses included semiquantitative myelin and quantitative axonal analysis. Compared with control specimens (P < .001, analysis of variance), specimens from patients with MS had smaller cord areas (mean area, 59.0 mm(2) +/- 12.5 vs 72.7 mm(2) +/- 10.0), significant prolongation of T1 (mean prolongation, 30%) and T2 (mean prolongation, 13%), and decreased MTRs (mean, 10.5%). Within MS specimens, 58% of the white matter area displayed signal intensity abnormalities on intermediate-weighted MR images. The number of axons i...Continue Reading

References

Apr 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·L S Honig, W A Sheremata
Feb 1, 1985·AJR. American Journal of Roentgenology·K R MaravillaR L Nunnally
Nov 1, 1994·Neuroradiology·M NagaoH Yamauchi
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F Barkhof, M van Walderveen
Jan 29, 2000·Brain : a Journal of Neurology·G LovasS Komoly
Mar 30, 2000·Journal of Neurocytology·C BjartmarB D Trapp
Aug 10, 2000·Journal of the Neurological Sciences·M RovarisM Filippi
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth P WhittallDonald W Paty
Feb 7, 2002·Journal of Neuropathology and Experimental Neurology·Jerome R WujekBruce D Trapp
Feb 1, 2003·Journal of the Neurological Sciences·C BjartmarB D Trapp

❮ Previous
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Citations

Mar 12, 2009·Neuroradiology·Mike P Wattjes, Frederik Barkhof
May 17, 2007·European Radiology·Yoshimitsu OhgiyaSven E Ekholm
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·W RashidD H Miller
Sep 5, 2009·AJNR. American Journal of Neuroradiology·A F MarlianiM Leonardi
Apr 30, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin D HarkinsMark D Does
Sep 18, 2007·Expert Review of Neurotherapeutics·L J EdwardsC S Constantinescu
Nov 26, 2015·NeuroImage. Clinical·Shannon KolindPeter A Brex
Nov 29, 2012·Neurologic Clinics·Mohammad Ali SahraianAlireza Minagar
Apr 1, 2013·Multiple Sclerosis and Related Disorders·H KearneyD H Miller
May 3, 2012·Neuroimaging Clinics of North America·Iris D KilsdonkMike P Wattjes
Apr 23, 2010·Magnetic Resonance Imaging·Jordan K LeitchPatrick W Stroman
Jan 31, 2009·Journal of the Neurological Sciences·J M StankiewiczR Bakshi
Dec 10, 2008·Neuroimaging Clinics of North America·Joseph C J Bot, Frederik Barkhof
Nov 4, 2015·Nature Reviews. Neurology·Christian EnzingerUNKNOWN MAGNIMS study group
May 12, 2007·Neuroimaging Clinics of North America·Majda M ThurnherChristina Mueller-Mang
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mark A Horsfield
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christopher R TenchCris S Constantinescu
Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·Lisa L CookStephen J Karlik
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Song FengHuan Yi
Jul 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Klaus SchmiererDavid H Miller
Jan 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Klaus SchmiererDavid H Miller
May 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth W FishbeinRichard G Spencer
Dec 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·T H KimE-K Jeong
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Qi-Zhu WuGary F Egan
Apr 23, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jonathan A D FarrellPeter C M van Zijl
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Irene M VavasourAlex L MacKay
Apr 26, 2011·Journal of Magnetic Resonance Imaging : JMRI·Lauren V ZollingerJohn W Rose
May 2, 2013·Journal of Magnetic Resonance Imaging : JMRI·Hugh KearneyDavid H Miller
Mar 7, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jiwon OhDaniel S Reich
Mar 21, 2006·Lancet Neurology·Marco RovarisMassimo Filippi
Jun 14, 2005·Journal of the Neurological Sciences·G J Lycklama à Nijeholt
Jan 18, 2011·NeuroImage·Eric C KlawiterTammie L Benzinger
May 27, 2015·Nature Reviews. Neurology·Hugh KearneyOlga Ciccarelli
Mar 10, 2015·Lancet Neurology·Achim GassUNKNOWN MAGNIMS Study Group
Dec 24, 2011·European Journal of Radiology·Fernanda Miraldi Clemente PessôaEmerson Leandro Gasparetto
Mar 19, 2014·Journal of Magnetic Resonance·Michal RivlinGil Navon

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