The spinal transmission of nociceptive information: modulation by the caudal medulla

Neuroscience
Didier BouhassiraD Le Bars

Abstract

Multiple descending systems for pain control originate from the rostral medulla and midbrain. These systems are involved in the antinociceptive action produced by opioids. One category of descending inhibitory controls is activated specifically by noxious stimuli and has been termed diffuse noxious inhibitory controls. These controls have been described in both animal and man, but their supraspinal circuitry has not been fully localized. To determine the supraspinal level of integration of nociceptor activated controls and hence their potential relationships with previously described descending controls, we studied in halothane-anesthetized rats the effects of transections performed at various levels in the brainstem. The physiological properties of dorsal horn convergent neurons, including supraspinally-mediated inhibitory processes elicited by heterotopic noxious stimuli, i.e. diffuse noxious inhibitory controls, were not altered in rats in which the brainstem had been completely transected up to 200 microns caudal to the caudal end of the rostral ventromedial medulla. In contrast, the spontaneous activity of these neurons was significantly enhanced and the inhibitory phenomena significantly reduced in animals with transectio...Continue Reading

References

Jun 5, 1992·European Journal of Pharmacology·D BouhassiraD Le Bars
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Citations

Feb 19, 2003·Brain Research. Brain Research Reviews·Daniel Le Bars
May 30, 2002·Progress in Neurobiology·Mark J Millan
Dec 24, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paolo RossiMariano Serrao
Sep 2, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mariano SerraoFrancesco Pierelli
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Prem BajajLars Arendt-Nielsen
Apr 12, 2003·Brain : a Journal of Neurology·Didier BouhassiraNadine Atta
Sep 11, 2014·Autonomic Neuroscience : Basic & Clinical·Kun LiuBing Zhu
Mar 2, 2006·Anesthesiology·Oliver H G Wilder-Smith, Lars Arendt-Nielsen
Jun 22, 2010·Life Sciences·Alexander Z TzabazisDavid C Yeomans
Apr 28, 2009·Progress in Neurobiology·Ryan K Butler, David P Finn
May 21, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Rolf-Detlef Treede
Apr 29, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L Colvin, M Fallon
Aug 20, 2005·Headache·Mariano SerraoFrancesco Pierelli
Mar 7, 2012·European Journal of Pain : EJP·Y BabaL Arendt-Nielsen
Mar 8, 2003·Alimentary Pharmacology & Therapeutics·B CoffinD Bouhassira
Mar 1, 2008·European Journal of Pain : EJP·Philippe GoffauxSerge Marchand
Jan 9, 2003·Best Practice & Research. Clinical Anaesthesiology·Steen Petersen-Felix, Lars Arendt-Nielsen
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G W Bornkamm, W Hammerschmidt
Sep 2, 1998·The American Journal of Physiology·D BouhassiraR Jian
Apr 29, 2021·Journal of Pain Research·Mateusz Wojciech KucharczykKirsty Bannister

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