The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio

Susan J HoodMorris J Brown


There is continuing variation in diagnosis and estimated prevalence of primary hyperaldosteronism. The higher estimates encourage search for adrenal adenomas in patients with elevated ratios of plasma aldosterone to renin. However, it is more likely that patients with normal plasma K+ and aldosterone belong to the polygenic spectrum of low-renin hypertension rather than have the same monogenic syndrome as classic Conn's. Our primary hypothesis was that in low-renin patients with normal plasma K+ and aldosterone, a thiazide diuretic, bendroflumethiazide, would be as effective as spironolactone in overcoming the Na+ retention and lowering blood pressure. Secondary objectives were to compare the dose response for each diuretic and to evaluate amiloride as an alternative to spironolactone. Fifty-seven patients entered and 51 patients completed a placebo-controlled, double-blind, randomized crossover trial. Entry criteria included low plasma renin, normal K+, elevated aldosterone-renin ratio, and a previous systolic blood pressure response to spironolactone of > or = 20 mm Hg. Two doses each of spironolactone and bendroflumethiazide were compared. The crossover also included amiloride and losartan. Outcome measures were blood pressu...Continue Reading


Dec 1, 1992·European Heart Journal·L E RamsayP R Jackson
Apr 14, 1990·BMJ : British Medical Journal·J E CarlsenP Johansen
Jun 25, 1983·British Medical Journal·J P Thomas, W H Thomson
Apr 1, 1994·Clinical and Experimental Pharmacology & Physiology·R D GordonJ C Rutherford
Apr 1, 1994·Clinical and Experimental Pharmacology & Physiology·M StowasserR D Gordon
May 1, 1993·Clinical and Experimental Pharmacology & Physiology·R D GordonS A Klemm
Nov 14, 1997·Journal of Hypertension·X JeunemaitreP Barbry
Mar 16, 2002·Journal of Human Hypertension·P L Padfield
Mar 23, 2002·Journal of Hypertension·Alison J DearyMorris J Brown
Jul 10, 2002·Hypertension·Emma H BakerGraham A MacGregor
Dec 7, 2002·Hypertension·David A CalhounPaula Weissmann
Oct 24, 2003·American Journal of Hypertension·Mari Konishi NishizakaDavid A Calhoun
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Feb 20, 2004·Journal of Human Hypertension·B WilliamsUNKNOWN British Hypertension Society
Apr 21, 2004·Journal of Hypertension·Norman M Kaplan
May 12, 2004·Molecular and Cellular Endocrinology·Michael Stowasser, Richard D Gordon
Sep 2, 2004·Clinical Chemistry·Deirdré HartmanGraham A Macgregor
Apr 2, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alun D Hughes
Jul 9, 2005·Journal of Hypertension·Norman M Kaplan
Mar 24, 2006·Expert Opinion on Pharmacotherapy·Salim Janmohamed, Pierre-Marc G Bouloux
May 4, 2006·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroMauro Maccario
Oct 27, 2006·Nature Clinical Practice. Nephrology·Vesna D GarovicStephen T Turner
Feb 9, 2007·The New England Journal of Medicine·William F Young
Feb 21, 2007·Hypertension·Theodore L Goodfriend
Feb 21, 2007·Hypertension·Neil ChapmanUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial Investigators

❮ Previous
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May 10, 2007·Heart·Morris J Brown
Apr 5, 2011·International Journal of Hypertension·Z Khawaja, C S Wilcox
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Oct 16, 2014·European Journal of Endocrinology·Laurence AmarPierre-Francois Plouin
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Aug 6, 2010·The Cochrane Database of Systematic Reviews·Josh BatterinkCurt T Fowkes
Dec 23, 2009·Nature Reviews. Endocrinology·Andreas TomaschitzThomas R Pieber
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