PMID: 2123858Dec 1, 1990Paper

The spoIIIA locus is not a major determinant of prespore-specific gene expression during sporulation in Bacillus subtilis

Journal of Bacteriology
N Illing, J Errington

Abstract

During sporulation in Bacillus subtilis, expression of several prespore-specific genes is strongly dependent on the spoIIIE and spoIIIG gene products. Previous reports have also indicated a requirement for the products of the spoIIIA locus. However, we have now systematically studied six different well-defined spoIIIA mutations and find that, relative to spoIIIE and spoIIIG mutations, they have only a minor effect on the expression of two different prespore-specific genes, spoVA and sspA. Moreover, we have shown that strain IS37, which has been used as a spoIIIA mutant in several previous studies, actually contains a lesion in the spo0A gene. We conclude that spoIIIA has a relatively minor or indirect role in the regulation of prespore-specific gene expression.

References

Oct 1, 1979·Journal of General Microbiology·H de Lencastre, P J Piggot
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E S MasudaY Kobayashi
Feb 1, 1989·Genes & Development·C Karmazyn-CampelliP Stragier
Feb 1, 1988·Journal of Bacteriology·S M Cutting, J Mandelstam
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·P SchaefferJ P Aubert

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