The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system.

Genetics
Alex K LancasterJoanna Masel

Abstract

Epigenetically inherited aggregates of the yeast prion [PSI+] cause genomewide readthrough translation that sometimes increases evolvability in certain harsh environments. The effects of natural selection on modifiers of [PSI+] appearance have been the subject of much debate. It seems likely that [PSI+] would be at least mildly deleterious in most environments, but this may be counteracted by its evolvability properties on rare occasions. Indirect selection on modifiers of [PSI+] is predicted to depend primarily on the spontaneous [PSI+] appearance rate, but this critical parameter has not previously been adequately measured. Here we measure this epimutation rate accurately and precisely as 5.8 x 10(-7) per generation, using a fluctuation test. We also determine that genetic "mimics" of [PSI+] account for up to 80% of all phenotypes involving general nonsense suppression. Using previously developed mathematical models, we can now infer that even in the absence of opportunities for adaptation, modifiers of [PSI+] are only weakly deleterious relative to genetic drift. If we assume that the spontaneous [PSI+] appearance rate is at its evolutionary optimum, then opportunities for adaptation are inferred to be rare, such that the [P...Continue Reading

References

Apr 1, 1981·Genetical Research·P M Lund, B S Cox
Dec 1, 1995·Yeast·R B WicknerH K Edskes
Jul 7, 1996·Journal of Theoretical Biology·M Lachmann, E Jablonka
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R Holliday, T Ho
May 20, 1999·Nature·W J Dickinson, J Seger
Aug 10, 1999·The Journal of Experimental Zoology·G P WagnerT F Hansen
Oct 12, 2000·Nature·L Partridge, N H Barton
Nov 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P D SniegowskiA Shaver
Mar 7, 2001·Current Biology : CB·J F Brookfield
Mar 29, 2001·Trends in Genetics : TIG·C Pál
Aug 28, 2003·Evolution; International Journal of Organic Evolution·Joanna Masel, Aviv Bergman
Feb 28, 2004·Seminars in Cell & Developmental Biology·Douglas M RudenXiangyi Lu
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
Mar 11, 2005·Journal of Theoretical Biology·Denise M WolfAdam P Arkin
Jul 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Toru NakayashikiReed B Wickner
Jun 3, 2006·Evolution; International Journal of Organic Evolution·Heather MaughanJoanna Masel
Aug 2, 2006·FEMS Yeast Research·Erlend AaJohn W Taylor
Oct 10, 2006·Current Biology : CB·Paul D Sniegowski, Helen A Murphy
Nov 14, 2006·Molecular Biology and Evolution·Michael G GiacomelliJoanna Masel
Nov 30, 2006·Yeast·Frank Shewmaker, Reed B Wickner
Jan 9, 2007·The American Naturalist·Joanna MaselHeather Maughan
Nov 1, 1943·Genetics·S E Luria, M Delbrück
Mar 21, 2007·Molecular Microbiology·Hiroshi Kurahashi, Yoshikazu Nakamura
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael Lynch
Jun 6, 2007·Molecular and Cellular Biology·Elizabeth M H TankHeather L True
Oct 5, 2007·Theoretical Population Biology·Oliver D King, Joanna Masel
Dec 7, 2007·Nature Reviews. Genetics·Massimo Pigliucci
Jan 19, 2008·Genetics·Gregory I Lang, Andrew W Murray
Mar 4, 2008·Journal of Evolutionary Biology·S B Joseph, M Kirkpatrick
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Isheng J TsaiVassiliki Koufopanou
Jun 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael LynchW Kelley Thomas
Dec 11, 2008·PLoS Biology·Jens TyedmersSusan Lindquist
Jan 21, 2009·Genetics·Joanna Masel, Cortland K Griswold

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Citations

Mar 15, 2013·Trends in Cell Biology·Gregory A Newby, Susan Lindquist
Feb 18, 2012·Nature·Randal HalfmannSusan Lindquist
Apr 28, 2010·Molecular BioSystems·James Shorter
Aug 13, 2011·The Journal of Biological Chemistry·Theodora C SideriChris M Grant
Aug 24, 2012·Biology Direct·Eugene V Koonin
Mar 4, 2014·PloS One·Aaron C Gonzalez NelsonEric D Ross
Aug 11, 2012·Genetics·Susan W Liebman, Yury O Chernoff
Jun 3, 2015·Annual Review of Ecology, Evolution, and Systematics·Mark L Siegal, Jun-Yi Leu
Oct 23, 2015·Molecular Biology of the Cell·Shaun H SpeldewindeChris M Grant
Mar 15, 2011·Seminars in Cell & Developmental Biology·Emily T Crow, Liming Li
Sep 20, 2015·Seminars in Cell & Developmental Biology·Mick F Tuite
Jun 2, 2011·Environmental and Molecular Mutagenesis·Matthew S Russell, John C March
Mar 19, 2014·Molecular Microbiology·Laura Westergard, Heather L True
Mar 5, 2015·Prion·Alvaro J AmorDale M Cameron
Jan 21, 2015·Molecular Microbiology·Victoria A DoroninaChris M Grant
Aug 4, 2011·Prion·Justin K Hines, Elizabeth A Craig
Jun 15, 2013·Prion·Alexander I Alexandrov, Michael D Ter-Avanesyan
May 17, 2014·Prion·Raimon Sabate
Jul 6, 2010·Trends in Genetics : TIG·Joanna Masel, Meredith V Trotter
Feb 11, 2015·FEMS Yeast Research·David M Garcia, Daniel F Jarosz
Dec 31, 2016·Molecular Microbiology·Zhiqiang DuLiming Li
Mar 11, 2017·Prion·Oleg N TikhodeyevStanislav A Bondarev
Oct 19, 2017·The Journal of Biological Chemistry·Atsushi OkamotoShin-Ichi Hoshino
Jul 14, 2018·PLoS Genetics·Sean M CascarinaEric D Ross
Oct 3, 2017·Prion·Douglas R Lyke, Anita L Manogaran
Feb 27, 2020·Molecular Biology and Evolution·Luke J Kosinski, Joanna Masel
May 8, 2010·Prion·Rodrigo Diaz-Espinoza, Claudio Soto
Aug 2, 2017·Journal of Genetics·Johannes Manjrekar
Jun 16, 2018·FEMS Yeast Research·Dustin K GoncharoffLiming Li
May 6, 2020·Nature Structural & Molecular Biology·Janice VillaliTricia R Serio
Apr 15, 2020·Nature Chemical Biology·Toshinobu ShidaMotomasa Tanaka

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