PMID: 6966177May 26, 1980Paper

The spontaneous firing patterns of forebrain neurons. V. Time course of changes in caudate unit activity following dopamine-depleting lesions

Brain Research
E Garcia-RillN A Buchwald

Abstract

The effects of unilateral medial forebrain bundle ("MFB") lesions on the spontaneous firing patterns of caudate neurons on both sides of the brain in cats were studied 3 days, 7 days and more than 2 weeks postlesion. Our results indicate that: (1) the spontaneous firing of neurons in the caudate nucleus ipsilateral to the lesion slows significantly by 3 days postlesion and returns to control values by 7 days postlesion, (2) the spontaneous activity of contralateral caudate neurons slows progressively with postlesion time and (3) these changes in neural activity are not correlated with changes in dopamine concentrations in the caudate nucleus.

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