PMID: 6170736Oct 1, 1981Paper

The spontaneously diabetic BB Wistar rat. Morphologic and physiologic studies of peripheral nerve

Journal of the Neurological Sciences
J R MendellP Thibert

Abstract

The spontaneously diabetic "BB" Wistar rat was examined for evidence of peripheral nerve abnormalities by a combined morphologic and physiologic approach. The studies were done on rats kept severely hyperglycemic and frequently ketotic. The peripheral nerves of the lower extremities, including the most distal nerves of the intrinsic foot muscles, revealed only minimal abnormalities by histologic and morphometric examination. Sciatic nerve conduction studies, however, measured over a 2-month period did not show a significant slowing in diabetics compared with age-matched controls, as well as between diabetics and weight-matched controls. In addition, fast anterograde axoplasmic transport studies were correlated with serum glucose results. Rats maintained severely hyperglycemic with or without ketosis had abnormal down flow rats of [3H]leucine compared to controls. Diabetic rats maintained with normal blood glucose levels showed no change in transport rates. These results suggested that persistent hyperglycemia in the "BB" Wistar rat produces significant physiologic but not significant structural abnormalities in the peripheral nerve.

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Citations

Dec 5, 2000·Muscle & Nerve·J G HeckmannB Neundörfer
Apr 1, 1992·Diabetes/metabolism Reviews·D R Tomlinson
Jul 5, 2001·Journal of Neuroscience Research·A A BrownS S Scherer
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May 1, 1991·Journal of Neurocytology·S S Tay, W C Wong
Oct 1, 1987·Journal of the Neurological Sciences·J P Robinson, D R Tomlinson
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Jul 8, 2008·Journal of the Peripheral Nervous System : JPNS·David R Tomlinson, Natalie J Gardiner
Nov 25, 2000·Journal of Applied Physiology·M A FahimW B Alshuaib
Aug 2, 2000·Endocrine Research·M A FahimW B Alshuaib
Feb 1, 1991·Muscle & Nerve·M S CaffertyL P Rowland
Jul 1, 1986·Diabetes Research and Clinical Practice

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