The Spot 42 RNA: A regulatory small RNA with roles in the central metabolism

RNA Biology
Cecilie Bækkedal, Peik Haugen

Abstract

The Spot 42 RNA is a 109 nucleotide long (in Escherichia coli) noncoding small regulatory RNA (sRNA) encoded by the spf (spot fourty-two) gene. spf is found in gamma-proteobacteria and the majority of experimental work on Spot 42 RNA has been performed using E. coli, and recently Aliivibrio salmonicida. In the cell Spot 42 RNA plays essential roles as a regulator in carbohydrate metabolism and uptake, and its expression is activated by glucose, and inhibited by the cAMP-CRP complex. Here we summarize the current knowledge on Spot 42, and present the natural distribution of spf, show family-specific secondary structural features of Spot 42, and link highly conserved structural regions to mRNA target binding.

References

Jul 5, 1979·Journal of Molecular Biology·B G Sahagan, J E Dahlberg
Jul 5, 1979·Journal of Molecular Biology·B G Sahagan, J E Dahlberg
Aug 1, 1987·Journal of Bacteriology·P W RiceJ E Dahlberg
May 1, 1988·Journal of Bacteriology·D A PolayesJ E Dahlberg
Jun 1, 1986·Journal of Bacteriology·G F Hatfull, C M Joyce
Jul 9, 2002·Genes & Development·Thorleif MøllerPoul Valentin-Hansen
Jan 20, 2009·Bioinformatics·Andrew M WaterhouseGeoffrey J Barton
Feb 7, 2009·International Journal of Systematic and Evolutionary Microbiology·Beile GaoRadhey S Gupta
Apr 8, 2011·Nucleic Acids Research·Ivica Letunic, Peer Bork
Mar 6, 2012·The EMBO Journal·Chase L BeiselGisela Storz
Nov 6, 2012·Nucleic Acids Research·Sarah W BurgeAlex Bateman
Sep 27, 2013·PLoS Pathogens·Cornelius SchmidtkeUlla Bonas
Jun 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xun WangHeon M Lim

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Citations

Dec 19, 2019·Microbiology and Immunology·Shigeaki MatsudaToshio Kodama
Feb 6, 2020·Nucleic Acids Research·Pilar Menendez-GilAlejandro Toledo-Arana
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mark N RaghebHoura Merrikh
Jun 10, 2021·Molecular Microbiology·Ying-Jung LaiTony Romeo
Aug 11, 2017·ACS Synthetic Biology·Abigail N LeistraLydia M Contreras

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Methods Mentioned

BETA
electrophoresis
filter binding

Software Mentioned

Jalview
Bacteria
Blastn
iTOL

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