The spread and control of norovirus outbreaks among hospitals in a region: a simulation model

Open Forum Infectious Diseases
Sarah M BartschBruce Y Lee

Abstract

Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated various norovirus outbreaks in different locations, both with and without contact precautions. At the lower end of norovirus reproductive rate (R0) estimates (1.64), an outbreak tended to remain confined to the originating hospital (≤6.1% probability of spread). However, at the higher end of R0 (3.74), an outbreak spread 4.1%-17.5% of the time to almost all other OC hospitals within 30 days, regardless of the originating hospital. Implementing contact precautions for all symptomatic cases reduced the probability of spread to other hospitals within 30 days and the total number of cases countywide, but not the number of other hospitals seeing norovirus cases. A single norovirus outbreak can continue to percolate throughout a system of different hospitals for several months and appear as a series of unrelated outbreaks, highlighting the need for hospitals within a region to more aggressively and cooperatively track and control an initi...Continue Reading

References

Jul 14, 1977·The New England Journal of Medicine·T A ParrinoN R Blacklow
Jan 1, 1990·The Journal of Infectious Diseases·P C JohnsonH B Greenberg
Jul 1, 1994·The Journal of Infectious Diseases·D Y GrahamM K Estes
Mar 31, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Walter ZinggChristian Ruef
Nov 10, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Henry M WuKelly Henning
Nov 10, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David J WeberWilliam A Rutala
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cecilia P JohnstonTrish M Perl
Apr 18, 2008·Journal of Clinical Microbiology·Elise T-V TuPeter A White
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruce Y Lee
Jun 7, 2008·The Journal of Pediatrics·Reina M Turcios-RuizHelena E Friss
Oct 2, 2008·Emerging Infectious Diseases·Robert L AtmarDavid Y Graham
Dec 17, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Manish M PatelUmesh D Parashar
Jan 1, 2009·Emerging Infectious Diseases·Janneke C M HeijneJacco Wallinga
Jan 24, 2009·The Journal of Hospital Infection·J VanderpasO Vandenberg
Oct 30, 2009·The New England Journal of Medicine·Roger I GlassMary K Estes
Sep 30, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Susan S HuangBruce Y Lee
Jan 5, 2011·Emerging Infectious Diseases·Elaine ScallanPatricia M Griffin
Feb 19, 2011·American Journal of Public Health·Bruce Y LeeSusan S Huang
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bruce Y LeeRobert R Muder
May 12, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bruce Y LeeSusan S Huang
Aug 2, 2011·Emerging Infectious Diseases·Aron J HallMarc-Alain Widdowson
Sep 21, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Taranisia MacCannellUNKNOWN Healthcare Infection Control Practices Advisory Committee-HICPAC
Feb 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Faizel H A SukhrieMarion Koopmans
Feb 4, 2012·American Journal of Infection Control·Emily RhinehartPatty Leeman
Feb 10, 2012·Epidemiology·Janneke C M HeijnePeter F M Teunis
Jan 9, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bruce Y LeeSusan S Huang
Feb 19, 2013·American Journal of Infection Control·Manish DoshiPeter Axelrod
Apr 11, 2013·Journal of the American Medical Informatics Association : JAMIA·Bruce Y LeeSusan S Huang
Jul 24, 2013·Emerging Infectious Diseases·Kirsten SimmonsBen Lopman
Jul 31, 2013·American Journal of Infection Control·Bruce Y LeeSusan S Huang
Dec 7, 2013·American Journal of Epidemiology·Ben LopmanUmesh Parashar

❮ Previous
Next ❯

Citations

Oct 22, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sean L BarnesMichael Rubin
Oct 13, 2017·Journal of the American Medical Informatics Association : JAMIA·Jason Cory Brunson, Reinhard C Laubenbacher
Jan 5, 2017·Nutrition Reviews·Bruce Y LeeJoel Gittelsohn

❮ Previous
Next ❯

Software Mentioned

RHEA
Regional Healthcare Ecosystem Analyst ( RHEA )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Bruce Y LeeSusan S Huang
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Chao-Chih LaiFang-Tzy Wu
The Western Journal of Medicine
A I GoldsteinM J Feldman
© 2022 Meta ULC. All rights reserved