The spread of primary late-onset focal dystonia in a long-term follow up study

Clinical Neurology and Neurosurgery
Marina SvetelVladimir S Kostic

Abstract

To determine spread of primary late-onset focal dystonia at a long-term follow up study. Available patients not lost to follow up from the initial cohort were reexamined to access course and spread of dystonia. In this prolonged follow-up (13.71 ± 5.6 years), it was possible to contact and include 66 out of 132 consecutive patients (50%) who had been diagnosed as primary focal dystonia at the Clinic of Neurology (Belgrade) from January 1990 to January 2000. Recalculation after inclusion of the new data for 66 patients revealed that the latency from the disease onset to dystonia spreading to the first new region was 4.9 ± 4.9 years, and to the second region 5.9 ± 8.8 years. An average time to disease progression was 12.39 ± 1.58, 6.34 ± 1.55 and 15.95 ± 1.43 for patients with torticollis, blepharospasm, and those with hand dystonia, respectively. The spread of dystonia in patients with the initial blepharospasm was faster, while patients with the writer's cramp could expect further progression even after longer periods of time. Older age at onset (p = 0.061), family history (p = 0.028) and the presence of tremor in the region affected by dystonia (p = 0.047) were the most powerful predictors of disease spreading. The majority of...Continue Reading

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Citations

Apr 27, 2016·Journal of Neurology·H A JinnahStewart Factor
Oct 19, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Scott A NorrisJoel S Perlmutter
Dec 19, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Brian D BermanJoel S Perlmutter
Aug 28, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Scott A NorrisJoel S Perlmutter
May 19, 2017·Frontiers in Neurology·Sarah Pirio RichardsonMark Hallett
Aug 5, 2017·Frontiers in Neurology·Ali G Hamedani, Daniel R Gold
Aug 7, 2018·F1000Research·Stephen Tisch
Apr 14, 2020·Neurologic Clinics·H A Jinnah
Jul 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Meng WangDavide Martino

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