The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling.

The Journal of Biological Chemistry
Robert B JonesSusan L Bellis

Abstract

Aberrant cell surface glycosylation is prevalent in tumor cells, and there is ample evidence that glycans have functional roles in carcinogenesis. Nonetheless, many molecular details remain unclear. Tumor cells frequently exhibit increased α2-6 sialylation on N-glycans, a modification that is added by the ST6Gal-I sialyltransferase, and emerging evidence suggests that ST6Gal-I-mediated sialylation promotes the survival of tumor cells exposed to various cell stressors. Here we report that ST6Gal-I protects cancer cells from hypoxic stress. It is well known that hypoxia-inducible factor 1α (HIF-1α) is stabilized in hypoxic cells, and, in turn, HIF-1α directs the transcription of genes important for cell survival. To investigate a putative role for ST6Gal-I in the hypoxic response, we examined HIF-1α accumulation in ovarian and pancreatic cancer cells in ST6Gal-I overexpression or knockdown experiments. We found that ST6Gal-I activity augmented HIF-1α accumulation in cells grown in a hypoxic environment or treated with two chemical hypoxia mimetics, deferoxamine and dimethyloxalylglycine. Correspondingly, hypoxic cells with high ST6Gal-I expression had increased mRNA levels of HIF-1α transcriptional targets, including the glucose ...Continue Reading

References

Apr 30, 2002·Experimental Cell Research·Shaoqiang LinPeter M Schlag
Sep 6, 2002·Biochemical Pharmacology·Gregg Semenza
Oct 16, 2002·Journal of Korean Medical Science·Yang-Sook ChunJong-Wan Park
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Jul 5, 2005·Biochimica Et Biophysica Acta·Julia I Bárdos, Margaret Ashcroft
Sep 8, 2005·Seminars in Cell & Developmental Biology·Patrick H Maxwell
Jan 9, 2007·Current Opinion in Genetics & Development·John D Gordan, M Celeste Simon
Jun 9, 2007·The Journal of Clinical Investigation·Carole PeyssonnauxRandall S Johnson
Apr 9, 2008·The Biochemical Journal·Patrick van UdenSonia Rocha
May 24, 2008·The Biochemical Journal·Agnes Görlach, Steve Bonello
Jul 2, 2008·Neoplasia : an International Journal for Oncology Research·Andreas-Claudius HoffmannPeter V Danenberg
Aug 16, 2008·Experimental Cell Research·Faheem M ShaikhSusan L Bellis
Jan 28, 2010·British Journal of Cancer·J M HeddlestonJ N Rich
Aug 5, 2010·Cell Stem Cell·Ahmed MohyeldinAlfredo Quiñones-Hinojosa
May 10, 2011·The Journal of Biological Chemistry·Amanda F Swindall, Susan L Bellis
Sep 21, 2011·The Journal of Biological Chemistry·Zhongyu LiuSusan L Bellis
Sep 22, 2011·International Journal of Cancer. Journal International Du Cancer·Aniket N TavareDaqing Ma
Dec 29, 2011·Frontiers in Bioscience (Elite Edition)·Anne Harduin-LepersPhilippe Delannoy
Jan 27, 2012·Journal of Vascular Surgery·Chung S LimAlun H Davies
Jun 16, 2012·Cancer Metastasis Reviews·Matthew J SchultzSusan L Bellis
Apr 13, 2013·Journal of Ovarian Research·Matthew J SchultzSusan L Bellis
Aug 14, 2013·Annual Review of Pathology·Gregg L Semenza
Sep 3, 2013·Nature Neuroscience·William A FlavahanAnita B Hjelmeland
Jun 21, 2014·Biochimica Et Biophysica Acta·Fabio Dall'OlioMariella Chiricolo
Jan 27, 2015·Annual Review of Pathology·Sean R StowellRichard D Cummings
Feb 24, 2015·Seminars in Nuclear Medicine·Neesha DhaniMichael Milosevic
Mar 3, 2015·Advances in Cancer Research·Naoyuki Taniguchi, Yasuhiko Kizuka
Apr 29, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jishun Lu, Jianguo Gu
Aug 21, 2015·Nature Reviews. Cancer·Salomé S Pinho, Celso A Reis
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Georgina N Masoud, Wei Li

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Citations

Oct 17, 2019·Medicines·Jennifer Munkley, Emma Scott
Jun 13, 2018·Biological Chemistry·Amanda P B AlbuquerqueEduardo I C Beltrão
Oct 16, 2019·Journal of Ovarian Research·Kaitlyn A DorsettSusan L Bellis
Jun 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Charles J Dimitroff
Aug 20, 2019·Oncology Letters·Rebecca GarnhamJennifer Munkley
Feb 20, 2019·Frontiers in Immunology·Mehrab NasirikenariJoseph T Y Lau
Nov 6, 2020·The Journal of Biological Chemistry·Colleen M BritainSusan L Bellis
Nov 7, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Divya ThomasPrakash Radhakrishnan
Dec 16, 2020·Glycobiology·Kaitlyn A DorsettSusan L Bellis
Jan 12, 2021·The Journal of Biological Chemistry·Colleen M BritainSusan L Bellis
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