The stability of a ketamine-morphine solution

Anesthesia and Analgesia
Roger SchmidJoel Katz

Abstract

Recent advances in acute pain mechanisms and management have implicated the N-methyl D-aspartate receptor-ion channel complex in the development of postoperative hyperalgesia and acute opioid tolerance. N-methyl D-aspartate receptor antagonists such as ketamine have been used increasingly in clinical studies in an effort to minimize acute postoperative pain and reduce opioid requirements. A mixture of ketamine and an opioid administered in the same solution and syringe would be a practical and useful technique for postoperative epidural analgesia, continuous IV infusion, or patient-controlled IV analgesia. We investigated the stability of a morphine sulfate and racemic ketamine solution in saline at pH 5.5-7.5 over a period of 4 days. Our study demonstrates that the ketamine-morphine mixture at a clinically relevant concentration seems to be stable at room temperature, at a wide range of pH values, for at least 4 days. Small-dose ketamine is used with increasing frequency in the acute postoperative setting as an adjunct to traditional opioid analgesics. We show that a racemic ketamine and morphine solution at a clinically relevant concentration seems to be stable at room temperature at a wide range of pH values for at least 4 d...Continue Reading

References

Mar 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K B JaveryG W Colclough
May 16, 1998·Pain·M H LauD J Morgan
Feb 3, 2000·British Journal of Anaesthesia·G AdriaenssensH F Adriaensen
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Citations

May 3, 2007·Journal of Veterinary Pharmacology and Therapeutics·A G P GuedesM A Rider
Aug 27, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Junfeng GuZhongyuan Xia
Apr 22, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Fuchao ChenBenhong Zhou
Jan 22, 2011·Paediatric Anaesthesia·Michelle C WhitePeter A Stoddart
Feb 22, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dimitri AncedyJoël Schlatter
Sep 7, 2004·British Journal of Anaesthesia·J R Sneyd

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