PMID: 39141Jun 1, 1979

The stability of betamethasone-17-valerate in semi-solid bases

The Journal of Pharmacy and Pharmacology
Y W Yip, L W Po

Abstract

The stability of betamethasone-17-valerate in semi-solid bases has been investigated. Emphasis has been placed on the stability problems which could arise upon dilution of proprietary preparations by the use of model systems. Betamethasone-17-valerate has been shown to decompose to betamethasone-21-valerate and betamethasone alcohol. Quantitation of the decomposition was by direct densitometry on thin layer chromatographic plates. The decomposition was found to be an apparent first order process and to depend on the diluent used and its concentration. Attempts were also made to relate the rate of decomposition to the pH of the base used, and to stabilize the products.

References

Jan 1, 1987·Journal of Pharmaceutical and Biomedical Analysis·M Cornarakis-Lentzos, P R Cowin
Oct 1, 1990·Journal of Clinical Pharmacy and Therapeutics·P ChristenB Gander
Apr 1, 1991·Journal of Clinical Pharmacy and Therapeutics·A R BarnesS B Watkiss
Oct 1, 1995·Journal of Clinical Pharmacy and Therapeutics·A R BarnesW J Irwin
Aug 1, 1995·The Journal of Pharmacy and Pharmacology·S ChenK M Tramposch
Jan 18, 2013·Indian Journal of Pharmaceutical Sciences·S U R KhattakK Usmanghani
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·K S RyattA Mehta
Jun 1, 1982·Journal of Clinical and Hospital Pharmacy·J F Smith
Jul 1, 1982·The British Journal of Dermatology·K S RyattR Swallow
Apr 1, 1986·Journal of Clinical and Hospital Pharmacy·P BoonsanerD De Rudder
May 1, 1995·The British Journal of Dermatology·S M WilkinsonM H Beck

Citations

Mar 1, 1978·Journal of Pharmaceutical Sciences·R E GrahamC T Kenner
May 1, 1964·Archives of Dermatology·A W MCKENZIE, R M ATKINSON

Related Concepts

Valerate
Betamethasone
Valerates
Cellestoderm
Ointment Bases
Betnovate
Drug Stability
Dilution Technique
Densitometry
Half-Life

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