PMID: 10354707Jun 4, 1999Paper

The STAT family of proteins in cytokine signaling

Progress in Biophysics and Molecular Biology
K Shuai

Abstract

It has now been well established that the STAT family of proteins play important roles in cytokine-mediated specific gene activation. Although significant progress has been made toward the understanding of the structure and function of STATs as well as the regulation of STAT signaling pathways, many important questions remain to be answered. STAT PTPase(s) and STAT serine kinase(s) which play important roles in regulating STAT activity have not been identified. In addition, the molecular mechanisms of the negative regulation of STAT signaling by recently discovered protein inhibitors and the crosstalk between STAT and other signal transduction pathways have not been understood. The JAK/STAT field remains to be challenging and exciting.

References

Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·C SchindlerJ E Darnell
Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M A PritchardA F Wilks
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A F Wilks
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N ReichJ E Darnell
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z ZhongJ E Darnell
Jun 1, 1995·Current Opinion in Immunology·L M Karnitz, R T Abraham
Oct 20, 1995·The Journal of Biological Chemistry·S UddinL C Platanias
Oct 19, 1995·Nature·J N Ihle
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Oct 27, 1995·The Journal of Biological Chemistry·S J HaqueB R Williams
Jan 1, 1995·Annual Review of Immunology·J N IhleO Silvennoinen
Apr 1, 1995·Current Opinion in Cell Biology·M Hochstrasser
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·T G BoultonG D Yancopoulos
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K D KhanA L Bothwell
Feb 1, 1995·Trends in Genetics : TIG·J N Ihle, I M Kerr
Jan 27, 1995·Cell·G B CohenD Baltimore
Oct 7, 1994·Cell·A Ciechanover
Apr 1, 1994·Current Opinion in Cell Biology·K Shuai
Sep 16, 1994·Science·J HouS L McKnight
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·T ImprotaJ E Darnell
Dec 1, 1993·Molecular and Cellular Biology·M DavidA C Larner
Jan 1, 1996·Molecular and Cellular Biology·S A QureshiJ E Darnell
Apr 18, 1996·Nature·K TakedaS Akira

❮ Previous
Next ❯

Citations

Dec 15, 2000·Medical Oncology·I A Voutsadakis
Jan 13, 2004·Biochemical and Biophysical Research Communications·Shunsuke NojiriMakoto Ito
May 5, 2001·Pharmacology & Therapeutics·C R Weinstein-OppenheimerJ A McCubrey
Aug 10, 2001·Cellular Signalling·T ZhuP E Lobie
Aug 2, 2005·Nature Reviews. Immunology·Ke Shuai, Bin Liu
Jan 22, 2000·The Biochemical Journal·S HaanF Schaper
Feb 14, 2002·British Journal of Haematology·Farhad RavandiZeev Estrov
Sep 16, 2009·Journal of Immunotherapy·Takaya TsunoKathryn C Zoon
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Jul 31, 2013·Molekuliarnaia biologiia·A V ShaposhnikovIu V Shidlovskiĭ
Sep 23, 2003·Journal of Cellular Physiology·Valentina CalòAntonio Russo
Aug 4, 2011·Journal of Molecular Recognition : JMR·Nicodemus MautsaGregory L Blatch
Mar 13, 2010·The EMBO Journal·Andrew J LeeShao-Cong Sun
May 30, 2006·Autonomic Neuroscience : Basic & Clinical·Denys V Volgin, Leszek Kubin
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Antonio AcetiMaurizio Sorice
Jul 21, 2007·Journal of Cutaneous Pathology·Patricia R CuryVera C de Araújo
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Michael Murray
Oct 8, 2004·Expert Opinion on Therapeutic Targets·James Turkson
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Weiguo ChenGurjit K Khurana Hershey
Apr 25, 2001·Biology of Reproduction·J SuterB R Rueda
Sep 11, 2007·Oral Oncology·Vera Cavalcanti de AraújoNey Soares de Araújo
Jun 13, 2000·Oncogene·N N Danial, P Rothman
Jan 16, 2003·FEBS Letters·Satoshi YamadaAkihiko Yoshimura
Aug 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Lihua WenJulang Li
Nov 19, 2003·The Journal of Biological Chemistry·Juan J Sironi, Toru Ouchi
Jan 17, 2014·International Journal of Oncology·Shu-Wei Wang, Yue-Ming Sun
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qian ZhangMariusz A Wasik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.