Dec 1, 1975

The state of prothrombin, plasminogen and fibrinogen in the newborn infant

Pathologie-biologie
G PotronW Mascre

Abstract

The esterase activity of thrombin and plasmin on artificial substrates was used to study the kinetics of these enzymes by Lineweaver and Burk's method. In the plasma of new-born infants, plasmin obtained from streptokinase has an avidity comparable with that in adults. Thrombin is obtained by the action of staphylocoagulase and taipan venom. Its avidity has important individual variations and is different from that in adults. An inhibitor is present both in the plasma and in the serum of the new-born. Fibrinogen was studied by variations in absorption of light during coagulation by thrombin. The abnormalities observed depend on the physical and clinical conditions of the medium (ph, osmolality). These characteristics depend on the age of the infant, but also seem to depend on the conditions of the sample and, in particular, on fibrinolytic reactions. The existence of foetal fibrinogen is discussed.

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Mentioned in this Paper

Arginine hydrochloride
Staphylocoagulase
Snake Venoms
Clotting Factor II Assay
Enzymes, antithrombotic
Fibrinogen
Fibrinogen Assay
Plasminogen Measurement
PLG
F2 gene

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