Dec 1, 1975

The state of prothrombin, plasminogen and fibrinogen in the newborn infant

G PotronW Mascre


The esterase activity of thrombin and plasmin on artificial substrates was used to study the kinetics of these enzymes by Lineweaver and Burk's method. In the plasma of new-born infants, plasmin obtained from streptokinase has an avidity comparable with that in adults. Thrombin is obtained by the action of staphylocoagulase and taipan venom. Its avidity has important individual variations and is different from that in adults. An inhibitor is present both in the plasma and in the serum of the new-born. Fibrinogen was studied by variations in absorption of light during coagulation by thrombin. The abnormalities observed depend on the physical and clinical conditions of the medium (ph, osmolality). These characteristics depend on the age of the infant, but also seem to depend on the conditions of the sample and, in particular, on fibrinolytic reactions. The existence of foetal fibrinogen is discussed.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Arginine hydrochloride
Snake Venoms
Clotting Factor II Assay
Enzymes, antithrombotic
Fibrinogen Assay
Plasminogen Measurement
F2 gene

About this Paper

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Thrombosis Et Diathesis Haemorrhagica
Y NemersonJ Jesty
Journal of Clinical Microbiology
Thomas VanasschePeter Verhamme
Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
A GirolamiP Saltarin
The Journal of Experimental Medicine
B LipińskiJ Jeljaszewicz
© 2020 Meta ULC. All rights reserved