PMID: 1213200Sep 1, 1975Paper

The state of the vascular net and the hematoencephalic barrier in the cerebral cortex of rats during hypoxic training

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
L N SimanovskiĭV M Bresler

Abstract

With the aid of vital contact microscopy of the brain cortex, a sharp increase up to 613.2% in the total length of capillaries for a space unit by the 60 th day of training was shown to occur in the pia and the cortex in the course the training for hypoxia. Also the excessive blood volume, enlargement and lengthening of the small arteries and veins as well as increase in the capillaries diameter by 25-30%, were noted. In the course of the training, the blood flow speed increases considerably in cortical vessels. Study of the cortical blood-brain barrier by means of supravital microfluorimetry showed that, in the course of the training, the acid stainer (fluorescin) permeability through the barrier does not decrease. The readjustment of the cortical vascular net during the training does not affect the blood-brain permeability.

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
A UnterbergA Baethmann
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
J A HolashP A Stewart
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
S NielsenO P Ottersen
Biulleten' eksperimental'noĭ biologii i meditsiny
V I Udovichenko, Iu M Shtykhno
© 2022 Meta ULC. All rights reserved